Thursday 16 October, 2025
PDF of poster Objectives: The overall objective is to implement a system which will ensure results from NONMEM analysis to…
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Different approaches to the development of a WBPBPK model with a series of barbiturates using population modelling
Thursday 16 October, 2025
Whole body physiologically based pharmacokinetic (WBPBPK) models are complex as they incorporate a lot of information coming from different sources…
Read moreMeloxicam for juvenile rheumatoid arthritis patients: Is dosing on a mg/kg body weight basis justified?
Thursday 16 October, 2025
Objectives & Background: Meloxicam is a nonsteroidal anti-inflammatory drug approved for the relief of the signs and symptoms of osteoarthritis…
Read moreCluster analysis : an alternative method for covariate selection in population pharmacokinetics modeling
Thursday 16 October, 2025
Objectives: A high covariate number could become problematic when one needs to determine the most significant variable combination, in order…
Read morePopulation Pharmacokinetic Analysis of Zarnestra Using Data From Phase I Clinical Trials
Thursday 16 October, 2025
Objective: To perform a population pharmacokinetic (PK) analysis of the phase I clinical trial data of a new anticancer drug,…
Read morePopulation Pharmacokinetics of rHuEpo in Healthy volunteers.
Thursday 16 October, 2025
Objectives. rHuEpo (Recombinant Human Erythopoientin-alpha) is approved in the US and EU for treatment of anemia in several indications, including…
Read moreIncorporating Uncertainty and Variability in the Physiological Parameters of a PBPK Model
Thursday 16 October, 2025
Background: PBPK models are used to scale animal PK to man. However, using average parameters, these models only give rise…
Read moreIncorporating Variability in WBPBPK Models: Application to Three Benzodiazepines with Extrapolation from Rat to Man
Thursday 16 October, 2025
Aim:Previously we developed a WBPBPK (Whole Body Physiologically Based Pharmacokinetic) model for diazepam in rat incorporating variability in drug dependant…
Read moreThe propagation of information in PK modelling: The use of IV information to support the analysis of PK data
Thursday 16 October, 2025
A logical method of information transfer from IV to oral data was investigated using four data sets generated from phase…
Read moreMultiple Imputation of Serum Creatinine
Thursday 16 October, 2025
For many drugs that are excreted renally, dosage regimens are often adjusted for renal function. Serum creatinine concentration is the…
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