Thursday 16 October, 2025
Computer-assisted trial design (CATD) approach in drug development has recently been increasing to assure qualitative and efficient conduct of clinical…
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Population pharmacokinetics of long-term methotrexate in children with lymphoblastic leukemia
Thursday 16 October, 2025
A high dose Methotrexate (HD MTX) protocol was used for long-term treatment of 37 children, 20 males and 17 females…
Read morePhenytoin covariate models for Michaelis-Menten pharmacokinetics in adult epileptic patients
Thursday 16 October, 2025
Phenytoin plasma concentration minima at steady state (Cmin) were monitored in 230 adult outpatients with epilepsy. The drug is metabolized…
Read moreVancomycin population pharmacokinetic analysis in patients with hematological malignancies
Thursday 16 October, 2025
PDF of poster Introduction: The population approach and pharmacodynamic criteria have become available as tools in individualized antimicrobial therapy, leading…
Read moreHandling Concentrations Below Quantification Limit in Population
Thursday 16 October, 2025
Three practical strategies for handling concentrations below the quantification limit (BQL) in the context of the estimation of population parameters…
Read morePopulation pharmacokinetic and pharmacodynamic modeling of etanercept using logistic regression analysis
Thursday 16 October, 2025
Objectives: To develop a population pharmacokinetic (PK) and pharmacodynamic model of etanercept in patients with rheumatoid arthritis (RA), using the…
Read moreValidation Of An Amikacin Population Pharmacokinetics Model To Be Used In Intensive Care Unit
Thursday 16 October, 2025
Introduction: Amikacin (AMIK) is one of the most useful aminoglycoside in the treatment of severe G-negative infections. Intensive care unit’s…
Read moreCefepime Monitoring in ICU Patients Using a Population Pharmacokinetic Approach
Thursday 16 October, 2025
Introduction: Cefepime is used in the treatment of severe infections caused by Gram-negative bacilli. Pharmacokinetic modifications observed in ICU patients…
Read moreThe Use Of Physiologically Based Pharmacokinetic (PBPK) Model In Drug Development
Thursday 16 October, 2025
In PBPK models, the kinetics of a drug is related to physiological parameters (such as blood flow and tissue size)…
Read morePharmacokinetic Mixed Effects Modelling of S16257 After Oral Administration in the Beagle Dog; Combined Analysis
Thursday 16 October, 2025
The objectives of the study were to build a population pharmacokinetic model for S 16257 after oral administration in dogs…
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