Thursday 16 October, 2025
PDF of poster Background/Aims: Exposure-response analysis of different types of clinical data (e.g., continuous, categorical, count) requires different modeling approaches….
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Development of a dosing strategy for enoxaparin in patients with renal impairment using a population pharmacokinetic approach
Thursday 16 October, 2025
Background: A dose adjustment strategy for enoxaparin in patients with renal impairment has recently been added to the product label…
Read moreUse of an indirect effect model to describe the mobilization of progenitor cells induced by AMD3100
Thursday 16 October, 2025
PDF of poster Background: AMD3100 is a small molecule CXCR4 antagonist that has been shown to induce the mobilization of…
Read morePopulation Pharmacokinetics and Effects of Efavirenz in HIV Patients
Thursday 16 October, 2025
Objectives: The reverse transcriptase inhibitor efavirenz is currently used at a fixed dose of 600 mg qd. Dosage individualisation based…
Read morePopulation PK Modeling of drugs exhibiting less than proportional increases in pharmacokinetics relative to increasing doses
Thursday 16 October, 2025
Purpose: To explore the approach to modeling drugs exhibiting less than proportional increases in pharmacokinetics relative to increasing doses. Methods:…
Read moreComparison of different approaches for the analysis of drug exhibiting nonlinearity of Cmax to increasing doses
Thursday 16 October, 2025
Purpose: The PK of compound X appeared to be nonlinear with Cmax increasing less than proportionally with increasing of dose….
Read morePopulation Pharmacodynamic Analysis of QTc Prolongation vs. Plasma Concentration
Thursday 16 October, 2025
Purpose: QTc prolongation has been extensively investigated as a predictor of cardiac toxicity, and has been shown to correlate with…
Read moreModeling of circadian effect on lung function in patients with chronic obstructive pulmonary disease
Thursday 16 October, 2025
PDF of posterObjectives: To model the circadian effect on lung function in patients with chronic obstructive pulmonary disease (COPD). Methods: Lung function…
Read moreComparing efficacy of 10mg vs 20mg ARAVA in treatment of rheumatoid arthritis: A Population PK / PD Analysis
Thursday 16 October, 2025
PDF of poster ARAVA is an isoxazole with immunosuppressive and anti-proliferate activity used for the treatment of rheumatoid arthritis. We…
Read moreThe Use Of A Stochastic Model For Data Exhibiting Heterogeneous Pharmacokinetics
Thursday 16 October, 2025
A stochastic compartmental model was developed to describe heterogeneous elimination kinetics of drugs. It is a probabilistic transfer model with…
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