Thursday 16 October, 2025
Identifying covariate relations is usually an important part of the development of population pharmacokinetics/pharmacodynamics (PK/PD) models. This is commonly a…
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Power, Selection Bias And Predictive Performance Of The Population Pharmacokinetic Covariate Model
Thursday 16 October, 2025
Identification and quantification of covariate relationships is an important part of population pharmacokinetic/pharmacodynamic (PK/PD) modeling. The covariate model is often…
Read morePopulation Pharmacokinetics of onercept in healthy subjects.
Thursday 16 October, 2025
Purpose: To develop a population pharmacokinetic (POPPK) model and to determine the covariates affecting the pharmacokinetics of onercept (recombinant human…
Read morePopulation pharmacokinetic/pharmacodynamic modelling of the haematological effects of the new anticancer drug diflomotecan: A combined analysis from the first two phase I studies
Thursday 16 October, 2025
Purpose: To develop a population pharmacokinetic/pharmacodynamic (pk/pd) model of diflomotecan to assist in the dosing and blood sampling strategies in…
Read morePharmacokinetics and Pharmacodynamics of Rocuronium bromide in patients undergoing brain surgery: Influence of chronic Phenytoin therapy
Thursday 16 October, 2025
Objective: The characterization of the influence of Chronic Therapy with Phenytoin (CPT) in the Pharmacokinetics (PK) and Pharmacodynamics (PD) of…
Read moreHandling of time-varying covariates in population model building.
Thursday 16 October, 2025
Time-varying covariates contain more, and to some extent different, information than time-constant covariates. As information is linked to the magnitude…
Read moreModelling of intra-individual and inter-individual variability in 1,3-butadiene metabolism
Thursday 16 October, 2025
While inter-subject variability is accounted for in population statistical models, less attention has been devoted to intra-subject variability. In this…
Read moreModelling of the effect of Topotecan on B cell subsets in tumor bearing rats.
Thursday 16 October, 2025
Zipped PDF of poster Propose: To increase the understanding of the dynamic regulation involved in the hematopoietic alterations observed after…
Read moreEstimating Bias In Parameters For Some NONMEM Models For Ordered Categorical Data
Thursday 16 October, 2025
Introduction Side effect data are commonly reported as ordered categorical data e.g. none, mild, moderate and severe. Oftentimes only a…
Read moreA Semi-Mechanistic Model For Quantification Of Lean Body Weight
Thursday 16 October, 2025
PDF of poster Introduction: Lean body weight (LBW) has been recommended to scale drug dose. The current estimate of LBW…
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