Thursday 16 October, 2025
PDF of poster Objectives: To present a method for analyzing side effect data where change in severity of the side…
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Pooled PK analysis of Interferon-beta-1a (Rebif), data obtained in healthy subjects and in patients.
Thursday 16 October, 2025
Introduction and Objectives: Recombinant human interferon-beta-1a (Rebif) is currently used for the treatment of multiple sclerosis and is being investigated…
Read moreUnderstanding the variability in clinical response to rufinamide, a new antiepileptic drug: a pooled PKPD analysis
Thursday 16 October, 2025
PDF of poster Background: Rufinamide is a new chemical entity developed for the treatment of epilepsy that modulates the activity…
Read moreModel-based drug development of a new anti-HIV drug
Thursday 16 October, 2025
PDF of poster Introduction: Maraviroc (UK-427,857) is an antiretroviral drug with a new mechanism of action. It is a CCR5…
Read morePopulation PK/PD modelling of a new MAO-B inhibitor in young and elderly healthy volunteers.
Thursday 16 October, 2025
The aim of this work was to investigate the population PK/PD relationship of SSR, a new MAO-B inhibitor, in healthy…
Read moreEfficiency of Using Population Pharmacokinetics to Demonstrate Bioequivalence with Sparse Sampling in Cancer Patients- A Trial Simulation with Etoposide
Thursday 16 October, 2025
Purpose Etoposide (VP16) is an antineoplastic agent used in various malignancies. Like many anticancer drugs, toxicities preclude testing VP-16 in…
Read moreAssessment of the Predictive Performance of a New Population Pharmacokinetic Model For Trastuzumab (Herceptin) and Simulation of Trastuzumab Steady-State Exposure During Long-Term Weekly Dosing.
Thursday 16 October, 2025
Purpose: To assess the predictive performance of a new population PK model for trastuzumab and to investigate inter-patient variability of…
Read moreModelling and Simulation of the Telephone Sexual Activity Daily Diary (TSADD) Data of patients with female sexual arousal disorder (FSAD) treated with sildenafil (Viagra).
Thursday 16 October, 2025
PDF of poster Objectives: To develop models to:i) Characterize the probability of sexual events and their satisfaction scores over time…
Read moreLearning about Covariate Relations in the Patient Population Based on Data from Multiple Studies – Consequences of Different Approaches
Thursday 16 October, 2025
PDF of poster Identification and quantification of covariate relationships is an important part of population pharmacokinetic/pharmacodynamic modelling and is usually…
Read moreThe Lasso – A Novel Method for Predictive-Covariate Modelling of Population Pharmacokinetics/Pharmacodynamics
Thursday 16 October, 2025
PDF of poster Objectives: To implement a new method (the LASSO) for covariate selection within NONMEM and to compare this…
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