Thursday 16 October, 2025
PDF of poster Introduction: The in vivo evaluation of the antitumor efficacy of compounds in animal models is a fundamental…
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Population pharmacokinetics model validation using Kinetica
Thursday 16 October, 2025
Purpose: To investigate the algorithms of population modeling and validation implemented in Kinetica applied to both rich data and sparse…
Read moreSimultaneous Population D-Optimal Designs of Pharmacokinetic-Pharmacodynamic Experiments
Thursday 16 October, 2025
Objectives: Experimental pharmacokinetic-pharmacodynamic (PK-PD) data in the literature are commonly fit to population PK-PD models via simultaneous model fitting, where…
Read moreSimultaneous population D-optimal designs for contrast enhanced MRI measurements of atherosclerotic plaque neovasculature.
Thursday 16 October, 2025
PDF of poster Objectives: Atherosclerotic plaque is a common cause of stroke. Furthermore, histology studies have shown a strong correlation…
Read moreMeta analysis and clinical trial simulation in drug development.
Thursday 16 October, 2025
Background: GSK123 is a potent and novel selective adenosine agonist under development for the inhaled treatment of asthma, chronic obstructive…
Read moreEvaluating the predictive power of the Fisher information matrix in population optimal experimental design
Thursday 16 October, 2025
PDF of poster Objectives: In previous work, we evaluated computed population optimal designs via simulation studies [1].   Others have evaluated optimal…
Read moreIntegrated population pharmacokinetic model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction.
Thursday 16 October, 2025
Aim: Cyclophosphamide (CP) and thiotepa (TT) are frequently administered simultaneously in high-dose chemotherapy regimens. The prodrug CP shows strong autoinduction…
Read morePopulation pharmacokinetics of cisapride in preterm and term neonates
Thursday 16 October, 2025
Background: Cisapride is used in neonates with gastro-oesophageal reflux. Nevertheless, only one pharmacokinetic study has been performed in this population….
Read morePopulation pharmacokinetics of high-dose etoposide in children receiving different conditioning regimens
Thursday 16 October, 2025
Objectives: Many conditioning regimens contain high dose (HD) etoposide (Eto). Linearity of pharmacokinetics for Eto from low dose (LD) to…
Read morePopulation Pharmacokinetics of Amphotericin B Lipid Complex in Neonates
Thursday 16 October, 2025
Objectives: Amphotericin B Lipid Complex (ABLC) is as effective but better tolerated as conventional amphotericin B. Little is known, however,…
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