Thursday 16 October, 2025
PDF of poster Introduction: Esmolol has recently been studied in two clinical trials from which population pharmacokinetics have been derived:…
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Establishing a tool for individualised dosing of gabapentin – The use of a non-parametric population kinetics model in the MM-USCPACK software, a new tool for clinical dosage optimization.
Thursday 16 October, 2025
To be able to use pharmacokinetic tools in clinical practice, they must be easily available to the physician at the…
Read moreA non-parametric (NPAG) population PK model of orally and intravenously administered linezolid.
Thursday 16 October, 2025
Objectives: Population PK of linezolid (LNZ) has been characterized in several relatively recent publications, but with divergent conclusions regarding linear…
Read moreA Markov Model For The Effect Of Covariates Including Drug Adherence On Longitudinal Viral Response In HIV Patients
Thursday 16 October, 2025
Objectives: We investigate the effect of adherence to prescribed antiviral drugs on viral response in PI treatment failures randomized to…
Read moreCharacterization of Cortisol Circadian Rhythm and Lack of Cortisol Suppression by a New Corticosteroid, Ciclesonide
Thursday 16 October, 2025
PDF of poster Objective: Ciclesonide (CIC) is a new inhaled glucocorticoid for the treatment of asthma that is converted into…
Read moreSimultaneous vs. Sequential Estimation in PK/PD Data Analysis
Thursday 16 October, 2025
Introduction Rational drug dosing requires knowledge of the dose[– concentration] – effect relationship, which can be obtained by estimating a…
Read morePopulation pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination
Thursday 16 October, 2025
Objective: Characterization of the pharmacodynamic interaction between the antiepileptic drugs tiagabine and lamotrigine on basis of the anticonvulsant effect in…
Read moreDevelopment and validation of a mechanism-based PK/PD model for the in vitro-in vivo prediction of QT prolongation by dofetilide
Thursday 16 October, 2025
PDF of poster Objectives: Drug-induced QT prolongation is an important biomarker for assessing the risk of heart arrhythmias and reflects…
Read moreDiscussion of criteria for evaluating the quality of glucose clamp studies
Thursday 16 October, 2025
The pharmacodynamic (PD) action of insulin and insulin analogues is the lowering of the blood glucose concentration (BG) by increased…
Read moreMarkedly different predictions about insulin PharmacoDynamic (PD) measurement feasibility in healthy subjects from recently proposed IntraVenousGlucoseToleranceTest (IVGTT)-based insulin-glucose models
Thursday 16 October, 2025
Objectives: Evaluating the correspondence between insulin PD measurements by glucose clamps and IVGTT-based insulin-glucose models. Methods: We compared two recent…
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