Thursday 16 October, 2025
PDF of poster Objectives: ORG25969 is a chemically optimized cyclodextrin designed to selectively bind to rocuronium, leading to a reversal…
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Comparing binary tree and automated machine learning covariate search strategies
Thursday 16 October, 2025
Covariate search strategies have provided some measure of controversy with respect to the identification of significant or correlated effects. Using…
Read moreSimultaneous fit of competing models as a model discrimination tool in Bayesian analysis
Thursday 16 October, 2025
PDF of poster Objectives: The most common method to discriminate between nested models in frequentist analyses is the likelihood ratio…
Read moreProbabilistic Risk Assessment Using Integrated Preclinical-Clinical PK/PD Modelling in NONMEM
Thursday 16 October, 2025
Objective: To assess the clinical risk of an adverse effect seen only in preclinical safety studies. Methods: PK + PD…
Read morePopulation PK/PD Modeling of Testosterone (T), LH and Dihydrotestosterone (DHT) Response to Single SC Degarelix in Male Volunteers
Thursday 16 October, 2025
The aim was to describe the response to degarelix, a GnRH antagonist for prostate cancer using nonlinear mixed effects modeling…
Read moreModeling the complex pharmacokinetic profiles of cyclosporin and of mycophenolate observed in the early post-transplantation period.
Thursday 16 October, 2025
PDF of poster Background: In the early post-grafting period, the pharmacokinetic profiles of immunosuppressive drugs are complex. The time-blood concentration…
Read morePharmacokinetics of cyclosporine in lung transplant patients with and without cystic fibrosis. A NONMEM analysis.
Thursday 16 October, 2025
Background: Cyclosporine (CsA) pharmacokinetics exhibits flat and delayed absorption profiles. Previously a model where the absorption time profile of CsA…
Read morePopulation Pharmacodynamic Analysis of Glucose and Insulin levels Evaluated with a Hot Glucose Minimal Model, a Total Glucose Minimal Model, and an Insulin Minimal Model
Thursday 16 October, 2025
Objective: To investigate differences in plasma glucose and insulin levels between volunteers and patients in the absence of drug, i.e.,…
Read morePopulation PK and PK/PD Analyses of an Enzyme Inhibitor in Healthy Volunteers
Thursday 16 October, 2025
PDF of poster Objectives: To develop a structural PK model and a structural PK/PD model in healthy volunteers. Methods: Single…
Read moreCounting events: population approaches using NONMEM
Thursday 16 October, 2025
PDF of poster Objectives: In drug development, there are examples in which pharmacotoxicological or clinical endpoints are expressed in terms…
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