Thursday 16 October, 2025
Objectives: The aim of the present analysis was to explore the possibility of implementing differential equations in the non-linear mixed-effects…
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NMQual: A Tool to Automate Installation and Facilitate Qualification of NONMEM
Thursday 16 October, 2025
PDF of poster Objectives: Keeping NONMEM installations up to date with known bugfixes can be challenging due to the nature…
Read moreSimultaneous Population Pharmacokinetic Model of AQUAVAN™ And AQUAVAN™-Derived Propofol
Thursday 16 October, 2025
Background: Propofol, an intravenous anesthetic agent, is used for the induction and maintenance of general anesthesia and sedation. Infusion of…
Read moreSample Size Calculation based on Confidence interval for Pharmacokinetic Studies
Thursday 16 October, 2025
An important consideration in applied science studies such as clinical trials is the number of subjects to be included in…
Read moreThe Design of Population Pharmacokinetic Studies: Sample Size Determination
Thursday 16 October, 2025
There is a need for pharmacokinetic(PK) studies just like any other study to include an adequate number of subjects in…
Read moreBispectral Index of AQUAVAN™-Derived Propofol: Population PK/PD Modeling and Application to an Effect – Controlled Trial
Thursday 16 October, 2025
Background: Propofol is an intravenous sedative-hypnotic agent used for the induction and maintenance of general anesthesia, and sedation. AQUAVAN≥ Injection…
Read morePopulation PK/PD model of GPI 15715 and GPI-derived propofol in sedation and comparison of PK/PD models for ordered categorical observations
Thursday 16 October, 2025
PDF of poster Objectives: AQUAVAN® Injection (GPI) is a water-soluble prodrug of propofol (PR). It was evaluated in an adaptive…
Read moreModeling & Simulation Approach to Discriminate True Food Effects: Comparison with Standard Noncompartmental Methods
Thursday 16 October, 2025
Objective: To explore differences in estimation methods to quantify food effect (FE) on absorption rate constant (Ka) between compartmental population…
Read moreA population PK model for nifedipine coat-core tablet
Thursday 16 October, 2025
PDF of poster Objectives: Adalat CR® tablet, which has been marketed since 1998 in Japan, is a coat-core tablet of…
Read moreModeling Discontinuation of Treatment in Non-Ignorable Situations
Thursday 16 October, 2025
PDF of poster Objectives: Clinical studies mostly generate incomplete data. The fraction of non-available data can range from small to…
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