Thursday 16 October, 2025
Introduction: The use of theoretical techniques for developing optimal designs for PKPD experiments has received some treatment in the pharmacology…
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A hidden markov model for characterizing the anti-migraine action of triptans
Thursday 16 October, 2025
Triptans (such as sumatriptan and naratriptan) are efficacious and specific medications in the treatment of migraine. Yet, assessing clear pharmacokinetic-pharmacodynamic…
Read moreComparison of sumatriptan and naratriptan using a markov model approach
Thursday 16 October, 2025
PDF of poster Triptans (such as sumatriptan and naratriptan) are efficacious and specific medications in the treatment of migraine. Yet,…
Read moreModelling of biomarker response of naproxen in rats and humans
Thursday 16 October, 2025
Introduction: Cyclo-oxygenase (COX) inhibitors are widely used to treat acute inflammation and pain. They act by inhibiting the activity of…
Read morePopulation semi-parametric modelling of the pharmacokinetics of rofecoxib in rats
Thursday 16 October, 2025
PDF of poster Objectives: Rofecoxib is a potent and highly selective cyclo-oxygenase-2 inhibitor and is often prescribed for human ailments…
Read morePopulation pharmacodynamic modelling of lanreotide (Lan) autogel (ATG) in patients with acromegaly
Thursday 16 October, 2025
PDF of poster Objective: To establish the concentration of Lan vs growth hormone (GH) response in patients with acromegaly over…
Read moreA Novel Method for Simulation of Correlated Continuous and Categorical Variables Using A Single Multivariate Distribution
Thursday 16 October, 2025
PDF of poster Introduction: Covariate distribution modeling (CDM) is used to generate virtual patients (covariate vectors), based on data from…
Read morePropagation of population pharmacokinetic information using a Bayesian approach
Thursday 16 October, 2025
PDF of poster Objectives: To investigate the propagation of population pharmacokinetic information across clinical studies by applying Bayesian techniques. The…
Read morePropagation of population PK and PD information using a Bayesian approach: dealing with non-exchangeability
Thursday 16 October, 2025
PDF of poster Objectives: To implement a conservative prior that safeguards against population non-exchangeability of prior and data likelihood, in…
Read morePopulation pharmacokinetic analysis of high-dose oral busulphan for bone marrow transplant in adults and children
Thursday 16 October, 2025
PDF of poster Objectives: To undertake a population analysis of high dose oral busulphan for bone marrow conditioning prior to…
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