Thursday 16 October, 2025
PDF of poster Objectives: A population pharmacokinetic model for a new compound under development in psychiatry was built based on…
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Influence of study design and interindividual variability on In Vitro – In Vivo Correlation evaluation
Thursday 16 October, 2025
Background. Although crossover studies are preferred to establish In Vitro – In Vivo Correlations (IVIVC), parallel studies are also acceptable…
Read morePopulation Whole Body Physiologically based Pharmacokinetic/Pharmacodynamic modelling in drug development: Impact of input parameters variability and incertainty on pharmacodynamic response
Thursday 16 October, 2025
Objectives:A Physiologically Based Whole Body Pharmacokinetic/ Pharmacodynamic (WBPBPK/PD) is today recognised as knowledge- based mechanistic modelling approach to integrate the…
Read moreUse population approach to characterize PK time-course with erratic absorption
Thursday 16 October, 2025
PDF of poster Objectives: Characterization of population pharmacokinetics of a new CNS compound explored in neurological and psychiatric disorder accounting…
Read moreCerebral uptake of mefloquine enantiomers with and without theP-gp inhibitor elacridar (GF1210918) in mice
Thursday 16 October, 2025
PDF of poster Objectives: Mefloquine is a chiral neurotoxic antimalarial agent showing stereoselective brain uptake in humans and rats. It…
Read moreBuilding a pharmacogenetic model to describe the pharmacokinetics of digoxin
Thursday 16 October, 2025
PDF of poster Objectives: Over the past few years pharmacogenetic data has become increasingly available. In pharmacokinetic (PK) or pharmacodynamic…
Read morePopulation Pharmacokinetic Study of Fotemustine
Thursday 16 October, 2025
The main purpose of this study was to perform the pharmacokinetic modelling of fotemustine (MUPHORANâ) and to improve the pharmacokinetic…
Read moreA Population Pharmacokinetic-Pharmacodynamic Model For Count Data: Application to the Effect of Atosiban on Uterine Activity in Preterm Labor Patients
Thursday 16 October, 2025
Objectives: The objective of this study was to quantify the relationship between drug exposure and the inhibitory effect of the…
Read moreTreatment Efficacy of Combination-Therapy based on a Mechanistic Characterisation of Disease Processes in Type 2 Diabetes Mellitus over a two-year period
Thursday 16 October, 2025
PDF of poster Objective Type 2 Diabetes Mellitus (T2DM) is a chronic progressive disease in which specific disease processes (i.e….
Read moreA Mechanistic Disease Progression Model for Type 2 Diabetes Mellitus and Pioglitazone Treatment Effects
Thursday 16 October, 2025
PDF of poster Objectives: Type 2 Diabetes Mellitus (T2DM) is characterized by the progressive failure of pancreatic b-cells to compensate…
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