Thursday 16 October, 2025
Objectives: the evaluation of the target site exposure is essential for a better understanding of the PK-PD relationships of locally…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Application of High-Throughput PBPK Modeling to Develop an IVIVE Approach for Oral Permeability
Thursday 16 October, 2025
Introduction Physiologically Based Pharmacokinetic (PBPK) modeling is a powerful tool for predicting drug absorption, distribution, metabolism, and excretion (ADME). Understanding…
Read moreComparison of Body Weight and Body Surface Area-Based Dosing in Paediatric Population using PBPK modelling
Thursday 16 October, 2025
Introduction Paediatric dose optimization is essential due to the physiological differences between children and adults. Given the variability in children’s…
Read moreInvestigating the hypothesis of lysosomal trapping of 1-hydroxymidazolam using PBPK modelling
Thursday 16 October, 2025
Introduction: One-hydroxy-midazolam (1’-OH-MDZ), the primary active metabolite of midazolam (MDZ), is formed predominantly through CYP3A4 metabolism [1]. Given MDZ’s role…
Read moreDeconvolution of Gastric Emptying based on interaction between Paracetamol and Liraglutide and its Extrapolation to Comedications using a PBPK Modeling approach
Thursday 16 October, 2025
Introduction: Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications intended to manage Type 2 diabetes, obesity and Metabolic…
Read moreA PBPK based simulation study to predict potential gastric transit time and permeability driven drug – drug interactions caused by Rybelsus® (semaglutide + SNAC)
Thursday 16 October, 2025
Introduction: Rybelsus® (semaglutide) is an oral medication used to manage type 2 diabetes by improving blood sugar levels. It is…
Read moreContinuous infusion simulations in PBPK and QSP models reveal steady-state properties and rate-limiting steps.
Thursday 16 October, 2025
Introduction: Mechanistic PK/PD, Whole-body PBPK and QSP models are increasingly popular in predicting preclinical and clinical studies in all stages…
Read moreAge-related changes in plasma proteins, haematocrit, and CYP3A4 activity for physiologically based pharmacokinetic (PBPK) model implementation in older adults
Thursday 16 October, 2025
Introduction: While older adults receive the vast majority of drug prescriptions, current formulations are based on clinical studies in younger…
Read moreLeveraging PBPK Modelling to Optimize Oligonucleotide Therapeutics: Sustained-Release Strategies for Enhanced Targeting Specificity
Thursday 16 October, 2025
Introduction: Oligonucleotide therapeutics offer a powerful approach for gene silencing across various disease areas, yet achieving efficient and tissue-specific delivery…
Read morePopulation pharmacokinetics of the antifungal immediate-release oral flucytosine to characterize absorption and food effects
Thursday 16 October, 2025
Objectives: Cryptococcal meningitis (CM) is an opportunistic fungal infection that predominates HIV/AIDS-related mortality, particularly in the sub-Saharan Africa region. An…
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