Thursday 16 October, 2025
Introduction Tacrolimus, a potent immunosuppressant commonly used to prevent organ transplant rejection, presents challenges in dosing due to its narrow…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Drug-Drug Interaction of Lamotrigine and Efavirenz during Pregnancy
Thursday 16 October, 2025
Introduction: Pregnant women with chronic conditions such as human immunodeficiency virus (HIV) face unique challenges in medication management due to…
Read moreIntegration of Physics-Informed Neural Networks with Physiologically-based Pharmacokinetic Modelling: A Novel Physics-based Framework for Parameter Discovery
Thursday 16 October, 2025
Introduction: A key fundamental challenge in physiologically-based pharmacokinetic (PBPK) modelling is the derivation of appropriate parameter values due to the…
Read moreCharacterization of the Drug–Drug Interaction potential of vorasidenib via PBPK modelling
Thursday 16 October, 2025
OBJECTIVES: vorasidenib is an orally available brain-penetrant and potent inhibitor of isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2) mutant proteins…
Read morePopulation analysis of the clinical pharmacokinetic characteristics of a letrozole long-acting injectable formulation
Thursday 16 October, 2025
Introduction. Letrozole is an aromatase inhibitor used as a first line treatment for hormone-dependent breast cancer in post-menopausal women and…
Read morePopulation pharmacokinetic analysis of doxecitine and doxribtimine in patients with thymidine kinase 2 deficiency and in healthy volunteers
Thursday 16 October, 2025
Introduction: Doxecitine and doxribtimine, a pyrimidine nucleoside therapy consisting of the two nucleosides doxecitine (deoxycytidine [dC]) and doxribtimine (deoxythymidine [dT]),…
Read morePredicting Hormonal Contraceptives Drug-Drug-Interactions by leveraging the model database of the Open Systems Pharmacology
Thursday 16 October, 2025
Objective Combined oral contraceptives (COCs) are commonly used worldwide to prevent unintended pregnancies. However, other medications can affect COCs’ metabolism,…
Read moreA PB-QSP module for ocular applications for the Open Systems Pharmacology – A vancomycin example
Thursday 16 October, 2025
Objectives Treatment of ocular disorders (e.g., eye infection or macular degeneration) often requires optimization of delivery of drugs to the…
Read moreThe Finite Absorption Time (F.A.T.) Concept: A new Model Informed Drug Development (MIDD) world is emerging in all phases of drug and generics development
Thursday 16 October, 2025
Introduction: Pharmacokinetic (PK) analyses, data evaluation, and simulations assume that absorption of drugs administered orally or otherwise lasts forever. This…
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