Thursday 16 October, 2025
Introduction: Abemaciclib is an orally administered drug targeting the cyclin-dependent kinase 4 and 6 (CDK4/6), responsible for tumour growth. It…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
A best practice framework for applying physiologically based pharmacokinetic modelling to predict pH-dependent Drug-Drug Interactions
Thursday 16 October, 2025
Introduction: Predicting drug-drug interactions (DDIs) involving acid-reducing agents (ARAs) is crucial for ensuring drug efficacy and patient safety, as well…
Read morePBPK Modeling Through Drug-Induced Liver Injury (DILI) Study by Nevirapine and Metabolite Concentrations in Liver Tissue and Blood
Thursday 16 October, 2025
Objectives: Accurate prediction of drug concentrations in liver tissue is essential for understanding drug-induced liver injury (DILI) mechanisms, especially in…
Read morePrediction of sildenafil concentrations in the central nervous system with physiologically based pharmacokinetic modelling
Thursday 16 October, 2025
Objectives The phosphodiesterase type-5 inhibitor sildenafil is widely used for the treatment of erectile dysfunction and pulmonary hypertension. As it…
Read moreIs flip-flop kinetics a myth?
Thursday 16 October, 2025
Introduction/ Objectives. Flip flop kinetics is being used in pharmacokinetics and pharmacometrics when following oral dosing the absorption half-life is…
Read more Development of network-based PBPK models to enhance the confidence in drug-drug interaction predictions
Thursday 16 October, 2025
Introduction: The use of physiologically based pharmacokinetic (PBPK) modeling in regulatory submissions has advanced significantly over time. Among the various applications…
Read morePhysiologically-based pharmacokinetic modeling to support submission of brigimadlin (BI 907828) in dedifferentiated liposarcoma
Thursday 16 October, 2025
Introduction: Brigimadlin is a highly potent, oral MDM2-p53 antagonist [1] for the treatment of cancer patients. After single dose administration,…
Read morePhysiologically based ocular models for protein therapeutics in rabbits and monkeys
Thursday 16 October, 2025
Objectives: Intravitreal (IVT) injection of protein therapeutics is widely used in the treatment of various ocular diseases. Physiologically based ocular…
Read moreVolume of Distribution Covariates That You May not Have Considered!
Thursday 16 October, 2025
Introduction: The volume of distribution (Vd) is a theoretical value defining the relationship between the measured systemic concentration and amount…
Read morePhysiologically-based toxicokinetic modelling of aluminium exposure in humans
Thursday 16 October, 2025
OBJECTIVES: Due to its toxic effects on bone, brain and liver at elevated exposure levels, a detailed understanding of Aluminium…
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