Thursday 16 October, 2025
Objectives: Association of drugs with chylomicrons (CM) in the enterocytes is a key process involved in intestinal lymphatic transport of…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Physiologically-based pharmacokinetic modeling of drugs metabolized via several CYP enzymes in populations of pregnant women
Thursday 16 October, 2025
Objectives: The objective of this study is to verify a physiologically-based pharmacokinetic (PBPK) model for the prediction of pharmacokinetics (PK) of…
Read moreCharacterization of paracetamol hepatotoxicity during pregnancy through physiologically-based pharmacokinetic modeling
Thursday 16 October, 2025
Introduction: Paracetamol (acetaminophen) is one of the most commonly prescribed drugs for acute pain during pregnancy [1]. Despite its frequent…
Read morePopulation pharmacokinetic analysis of inhaled budesonide in asthma patients
Thursday 16 October, 2025
Objectives: To apply population pharmacokinetic modeling in order to describe the absorption and distribution kinetics of budesonide in asthma patients after…
Read moreEvaluation of the impact of undernourishment on the intestinal absorption of gefitinib in rats.
Thursday 16 October, 2025
Objectives: The influence of undernutrition on the intestinal absorption of gefitinib, a tyrosine kinase inhibitor, has not been previously evaluated….
Read morePredicting diclofenac systemic and synovial fluid concentrations after dermal application using the Multi-Phase Multi-Layer MechDermA PBPK model
Thursday 16 October, 2025
Objectives: To assess the prediction performance of the MPML MechDermA model. The ultimate goal is to develop a flexible simulation framework…
Read morePrediction of the pharmacokinetics of renally excreted antiretrovirals in older patients, using physiologically based pharmacokinetic (PBPK) modelling.
Thursday 16 October, 2025
Objectives: Despite our knowledge of diminishing renal function with advancing age, information on the impact of aging on the pharmacokinetics (PK)…
Read moreAntidepressants, anxiolytics and statins: prediction of exposure changes due to aging
Thursday 16 October, 2025
Objectives: Antidepressants, anxiolytics and statins are commonly prescribed in elderly patients. This group of patients are generally not included in…
Read moreDistinguishing between first-pass and systemic CYP3A-mediated metabolism of midazolam in preterm neonates using physiologically-based pharmacokinetic modelling
Thursday 16 October, 2025
Objectives: Most pharmacokinetic (PK) models do not discriminate between presystemic (intestinal and first-pass hepatic) and systemic (hepatic) CYP3A-mediated metabolism of midazolam,…
Read moreApplication of a physiologically-based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat to improve dosing regimens in adults
Thursday 16 October, 2025
Objectives: First, to develop a PBPK model of the HDAC inhibitor vorinostat for adults [1]. Second, to link the PBPK…
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