Thursday 16 October, 2025
Objectives: PBPK modeling is a powerful tool to explore and quantitatively predict the magnitude of drug-drug interactions (DDIs) and may…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Physiologically-based pharmacokinetic (PBPK) modeling of the strong CYP1A2 inhibitor fluvoxamine
Thursday 16 October, 2025
Objectives: Fluvoxamine is described as a potent CYP1A2 and CYP2C19 inhibitor. The US Food and Drug Administration (FDA) recommends fluvoxamine…
Read morePhysiologically-based Pharmaokinetic Modelling of Metoprolol Drug-Drug-Gene Interactions with Paroxetine and CYP2D6
Thursday 16 October, 2025
Introduction: Metoprolol is on the World Health Organization’s “List of Essential Medicines” and the most frequently prescribed β1-receptor blocker in…
Read morePhysiologically-based Pharmacokinetic (PBPK) Modeling of Simvastatin Drug-Drug Interactions with Rifampin, Clarithromycin and Drug-Gene Interaction with ABCG2
Thursday 16 October, 2025
Objectives: To build and evaluate a PBPK model for simvastatin lactone (SL) for the prediction of drug-drug interactions (DDIs) with…
Read moreA size- and location-structured model for pulmonary absorption, elimination and dissolution of an orally inhaled drug
Thursday 16 October, 2025
Objectives: Pulmonary absorption of orally inhaled drugs depends on the deposition pattern, dissolution process, and mucociliary clearance. Especially for slowly…
Read moreDevelopment of a Semi-mechanistic absorption model for explaining effect of food on itraconazole
Thursday 16 October, 2025
Objectives: Oral administration of drugs has several advantages over other administration routes including lack of pain, easy to administer, portability…
Read moreExtension of a pregnancy physiologically-based pharmacokinetic model for renally cleared drugs to the postpartum period
Thursday 16 October, 2025
Objectives: The objective of this study is to extend a pregnancy physiologically-based pharmacokinetic (PBPK) model to the postpartum period and…
Read moreA Population Physiologically-Based Pharmacokinetic Model for prediction of pharmacokinetics of small molecule drugs in healthy Japanese adults: Bridging PBPK from Caucasian to Japanese ethnicity
Thursday 16 October, 2025
Objectives: Physiologically-based pharmacokinetic (PBPK) modeling is considered a valuable tool for predicting pharmacokinetic changes of drugs in different populations to…
Read moreWhich data are necessary to build a WB-PBPK model that accurately predicts exposure in the lung? A case study using Ethambutol for tuberculosis treatment
Thursday 16 October, 2025
Objectives: Characterising exposure profiles in different organs is a key feature of Whole-Body Physiologically–Based Pharmacokinetic (WB-PBPK) models. However, it remains…
Read moreProspective predictions of drug pharmacokinetics and food effect in pediatrics via PBPK modelling
Thursday 16 October, 2025
Introduction: Physiologically Based PharmacoKinetics (PBPK) models have become an important tool in drug development. They are increasingly used for various…
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