Thursday 16 October, 2025
Objectives: Pioglitazone, a thiazolidinedione, is indicated to treat type II diabetes mellitus. It is an agonist of the nuclear transcription factor…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Physiologically-based pharmacokinetic modeling of gemfibrozil drug-drug interactions with the CYP2C8 victim drugs repaglinide and pioglitazone
Thursday 16 October, 2025
Objectives: Physiologically-based pharmacokinetic (PBPK) modeling is a valuable tool to describe and predict the extent of drug-drug interactions (DDIs) and to…
Read morePhysiologically-based pharmacokinetic modeling of the CYP2C8 perpetrator trimethoprim
Thursday 16 October, 2025
Introduction: Trimethoprim is applied alone or in combination with sulfamethoxazole to treat bacterial infections by inhibition of bacterial folic acid…
Read moreHow can we inform human intestinal permeability with Caco-2 permeability using PK-Sim®?
Thursday 16 October, 2025
Introduction/Objectives: Oral drug bioavailability (Foral) can be expressed as the product of the (soluble) drug fraction absorbed from the gut lumen…
Read moreDevelopment and evaluation of a PBPK model to study the pharmacokinetics of inhaled drugs in rats
Thursday 16 October, 2025
Objectives: development and evaluation of a PBPK model to study the pharmacokinetics of inhaled drugs in rats, using test compounds…
Read moreEvaluation of a minimal WB-PBPK platform supporting different routes of administration
Thursday 16 October, 2025
Objectives: Assessing in different species a minimal whole-body (WB) PBPK platform, implemented in Matlab from literature information, able to predict,…
Read moreEvaluating the inclusion of the particle size distribution in the lung dissolution model of a WB-PBPK model to describe the pharmacokinetics of inhaled polydisperse drugs.
Thursday 16 October, 2025
Objectives: evaluating the impact of the particle size distribution of a polydisperse powder of inhaled drugs (compared with a monodisperse…
Read moreComparison of pharmacokinetic parameters estimated by the experimental R package ‘nlmixr’ and MONOLIX
Thursday 16 October, 2025
Objectives: To develop a compartment model for infusion data and to compare its parameter estimates produced by two functions of the…
Read moreEnhancing the predictive accuracy of PBPK models for drug concentrations in tissues: accounting for the impact of relative distribution of blood flow
Thursday 16 October, 2025
Introduction: Physiologically based pharmacokinetic (PBPK) models are a crucial tool for model-informed drug development and are increasingly being explored for…
Read moreA Whole body Physiologically based Pharmacokinetic Model for Antibody drug conjugates – model development and validation in rat
Thursday 16 October, 2025
Objectives: To develop and qualify a whole body physiologically-based Pharmacokinetic model for simulating Antibody Drug Conjugates (ADCs) disposition in tissues. Methods: The…
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