Thursday 16 October, 2025
Objectives: The rate of emptying of gastric contents into duodenum defines the availability of orally administered drugs for their absorption…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Transporter inhibition: modelling in-vitro Transwell assays
Thursday 16 October, 2025
Objectives: Transporter inhibition can have an impact on the disposition of a drug as well as on its safety and…
Read moreMechanistic modelling of in-vitro bidirectional permeability studies and in vivo absorption of metoprolol
Thursday 16 October, 2025
Objectives: Bidirectional transport assays can be used to obtain in vitro permeability estimates for use in PBPK models. However, the…
Read morePredicting human foetal exposure using physiologically based pharmacokinetic models
Thursday 16 October, 2025
Objectives: Pregnant women and their foetuses are exposed to numerous drugs. However, due to obvious ethical reasons in vivo foetal risk…
Read moreDevelopment of a PBPK model to predict the pharmacokinetics of cefuroxime during surgery
Thursday 16 October, 2025
Objectives: The goal of this study is to predict the plasma and tissue concentrations of the cephalosporine antibiotic cefuroxime during surgery….
Read moreEvaluating New Dosing Strategies for the Use of Cefuroxime in Perioperative Antibiotic Prophylaxis using PBPK
Thursday 16 October, 2025
Objectives: Optimization of the perioperative antibiotic prophylaxis (PAP) is still a matter of debate. Despite existing guidelines and recommendations, there…
Read moreA Mechanistic Cellular Disposition Model of Bile Acid Handling in Sandwich-Cultured Human Hepatocytes
Thursday 16 October, 2025
Objectives: To develop a physiological model which describes hepatic uptake, metabolism and biliary excretion of the bile acids (BAs) chenodeoxycholic acid…
Read moreMultiscale mechanistic models in Systems Pharmacology: development of a model describing Atorvastatin pharmacokinetics through integration of metabolic network in Physiologically Based Pharmacokinetic models.
Thursday 16 October, 2025
Objectives: This work aims to develop a Whole Body Physiologically Based Pharmacokinetic (WB-PBPK) model of Atorvastatin (AS), an HMG-CoA reductase…
Read moreGlobal sensitivity analysis of a physiologically based pulmonary absorption model
Thursday 16 October, 2025
Objectives: We performed a global sensitivity analysis (GSA) on an in-house physiologically based pulmonary absorption model for rats [1]. Physiological…
Read moreSensitivity analysis of P-glycoprotein Ki values in dynamic DDI predictions
Thursday 16 October, 2025
Objectives: The advantages of using PBPK models for prediction of transporter-mediated DDIs have been recognised [1]; although at present the…
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