Thursday 16 October, 2025
Objectives: Scarce data are available to guide cefazolin dosing in children undergoing cardiac surgery with cardiopulmonary bypass[1,2]. The objective of…
Read morePoster: Drug/Disease modeling - Paediatrics
Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults
Thursday 16 October, 2025
Objectives: In order to characterize the variation in pharmacokinetics of paracetamol across the human age span, we performed a population…
Read morePrimary microcephaly: do all roads lead to Rome?
Thursday 16 October, 2025
Objectives: Symmetric intrauterine growth restriction (IUGR) has been used to describe a growth pattern when all biometric measurements appear affected to…
Read moreEvaluation of gentamicin and tobramycin dosing guidelines for neonates; towards model-based dosing
Thursday 16 October, 2025
Objectives: Recently, a neonatal pharmacokinetic model for amikacin has been published upon which a novel model-based dosing regimen was proposed…
Read moreMorphine efficacy in mechanically ventilated preterm neonates; an item response theory analysis
Thursday 16 October, 2025
Objectives: It has proven difficult to identify and quantify analgesic efficacy of morphine in newborns. This study aimed to assess…
Read morePopulation pharmacokinetics of lacosamide to support intravenous dose adaptation in children with epilepsy
Thursday 16 October, 2025
Objectives: To predict the intravenous (IV) PK profile of lacosamide (LCM) in children, by combining the healthy adult IV and…
Read morePopulation pharmacokinetics of intravenous albuterol in children with status asthmaticus
Thursday 16 October, 2025
Objectives: To develop a population pharmacokinetic model of R-albuterol and S-albuterol for children suffering from status asthmaticus following continuous intravenous…
Read morePharmacokinetics of Pentobarbital in Pediatric Status Epilepticus Patients
Thursday 16 October, 2025
Objectives: Status epilepticus (SE) is a life threatening event which requires immediate medical intervention. The overall mortality in children treated…
Read morePopulation Pharmacokinetics of Ofloxacin in South African children
Thursday 16 October, 2025
Objectives: Multidrug-resistant tuberculosis (MDR-TB) is an emerging problem, increasingly affecting children. Ofloxacin is a fluoroquinolone widely used in the treatment and…
Read moreOptimisation of tacrolimus-based immunosuppressive treatment in pediatric solid organ transplantation: A model-based approach.
Thursday 16 October, 2025
Background: Tacrolimus is considered to be the mainstone of immunosuppressive therapy after solid organ transplantation. However, if its efficacy is…
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