Thursday 16 October, 2025
Objective: Imipenem is a broad spectrum antibiotic used to treat severe infections in critically ill patients. Imipenem pharmacokinetics (PK) was…
Read morePoster: Drug/Disease modeling - Paediatrics
Characterizing age-dependency of cytokine levels in healthy children
Thursday 16 October, 2025
Objectives: To characterize the age-dependency and normal ranges of eight cytokines in healthy children (IL-1ra, IL-2, IL-4, IL-6, IL-10, IP-10,…
Read moreRaltegravir dosing in neonates (IMPAACT P1110) – Use of allometry and maturation in PK modeling to develop a daily dosing regimen for investigation during the first weeks of life.
Thursday 16 October, 2025
Objectives: To determine a raltegravir (RAL) daily dosing regimen for prevention or treatment of HIV infection in 0-6 week old…
Read moreEvaluation of changes in oral drug absorption in preterm neonates for BCS class I and II compounds
Thursday 16 October, 2025
Objectives: Evidence suggests that the rate of oral drug absorption changes from birth, yet, the clinical implications are currently unclear, in…
Read moreA Bayesian approach for population pharmacokinetic modeling of dexmedetomidine during long-term infusion in critically ill pediatric patients.
Thursday 16 October, 2025
Objectives: The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the long-term…
Read morePopulation exposure-response modeling of oral nepadutant administration in infants with colic
Thursday 16 October, 2025
Objectives: Nepadutant is a potent antagonist of tachykinin NK2 receptors found to control the gastrointestinal hypermotility. In NIC-03, a phase…
Read moreModeling and simulation of dihydroartemisinin (DHA) after administration of Eurartesim® (piperaquine tetraphosphate/DHA)
Thursday 16 October, 2025
Objectives: Develop a population pharmacokinetic (PK) model for DHA by pooling data from 5 studies and apply it to predict…
Read moreModeling and simulation of smear count after administration of Eurartesim® (piperaquine (PQ) tetraphosphate/dihydroartemisinin (DHA)) in infected patients with Plasmodium falciparum malaria
Thursday 16 October, 2025
Objectives: Develop a population pharmacokinetic and pharmacodynamic (PK/PD) model for the treatment and smear count of Plasmodium falciparum by pooling…
Read moreDevelopment of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients
Thursday 16 October, 2025
Objectives: Unfractionated heparin (UFH) is the anticoagulant of choice in paediatric patients undergoing a variety of cardiac procedures. The ability to…
Read morepiperacillin-tazobactam pharmacokinetics in critically ill children: implications on adequate dosing regimens
Thursday 16 October, 2025
Objectives:The objective of this study was to investigate the pharmacokinetics of piperacillin and tazobactam in critically infants and children. Methods: This…
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