Thursday 16 October, 2025
Objectives: Midazolam is a commonly used CYP3A4 metabolized benzodiazepine for preoperative sedation in pediatric anesthesia. Although there are numerous studies…
Read morePoster: Drug/Disease modeling - Paediatrics
Pharmacometric approach to characterize key metabolites of acetaminophen in preterm and term neonates
Thursday 16 October, 2025
Objectives: Neonates of all gestational ages perceive pain [1]. Due to undesired side effects of opioids, acetaminophen (APAP) is used…
Read moreUsing extrapolation to support a pediatric investigational plan: an application in liver transplantation development
Thursday 16 October, 2025
Objectives: Support a pediatric investigational plan (PIP) for everolimus® in liver transplantation (Tx) in 2015, using a model based approach. Methods: The…
Read morePopulation pharmacokinetic modeling of Thymoglobulin in children receiving allogeneic-hematopoietic cell transplantation (HCT): towards individualized dosing to improve survival
Thursday 16 October, 2025
Objectives: To prevent graft versus host disease (GvHD) and rejection in hematopoietic cell transplantation (HCT), children receive anti-thymocyte globulin (ATG),…
Read moreModelling CD4 T cell reconstitution in HIV-infected children starting antiretroviral therapy
Thursday 16 October, 2025
Objectives: Antiretroviral therapy (ART) is the standard treatment for adults and children infected with human immunodeficiency virus (HIV). HIV mainly infects…
Read morePopulation pharmacokinetics of benzylpenicillin in neonates in routine care
Thursday 16 October, 2025
Objectives: Penicillin G remains widely used in neonates and, with gentamicin, it forms the mainstay of standard treatment for early…
Read moreSimultaneous modelling of antimicrobial pharmacokinetic data from birth to adolescence: using different penicillins to inform a common maturation function
Thursday 16 October, 2025
Objectives: Developmental physiology and ontogeny are known to affect drug disposition in neonates and children. Thus improving our understanding of…
Read moreModelling CD4 lymphocyte reconstitution following paediatric haematopoietic stem cell transplantation
Thursday 16 October, 2025
Objectives: Before a haematopoietic stem cell transplant (HSCT), a child will usually be given a conditioning regimen to reduce or ablate…
Read morePopulation pharmacokinetic analysis of hydrocortisone in paediatric patients with adrenal insufficiency
Thursday 16 October, 2025
Objectives: Patients with congenital adrenal hyperplasia (CAH) have an impaired synthesis of cortisol, leading to accumulation of cortisol precursors and…
Read moreSimulations to simplify gentamicin dosing regimens for neonates and young infants when referral is not possible in developing countries
Thursday 16 October, 2025
Objective: To provide a simple gentamicin dosing regimen recommendation for outpatient treatment of neonates and young infants (0 – 59…
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