Thursday 16 October, 2025
Objectives: Alzheimer disease (AD) is the most common form of senile dementia. Amyloid beta peptide in the brain is a…
Read morePoster: Applications- CNS
Title: Modeling exposure-response relationships in the rat self-administration model
Thursday 16 October, 2025
Background: There is a growing emphasis on the development of methodologies to derisk the abuse potential of drug candidates [1]….
Read moreApplication of PK/PD modelling in the development eletriptan DR for the treatment of acute migraine and prevention of headache recurrence.
Thursday 16 October, 2025
PDF of posterIntroduction: Eletriptan (Relpaxâ) is a potent, selective, 5-HT1B1D receptor agonist which is approved as an immediate release (IR)…
Read moreExposure-response modeling of daily seizure counts in focal epilepsy trials
Thursday 16 October, 2025
Objectives: To describe the change from baseline in individual seizure occurrences after treatment with brivaracetam or placebo in adjunctive treatment…
Read moreLevetiracetam exposure-response analysis in children with partial onset seizures
Thursday 16 October, 2025
Objectives : To compare the performance of several seizure count-based exposure-response models for levetiracetam in children with epilepsy and to…
Read moreDose-response population modeling of the new antiepileptic drug brivaracetam in add-on treatment of partial onset seizures.
Thursday 16 October, 2025
Objectives: To describe the individual change in seizure frequency from baseline after treatment with brivaracetam or placebo, to model the…
Read morePopulation Pharmacokinetic-Pharmacodynamic modelling of olanzapine effects on the electroencephalogram in healthy volunteers.
Thursday 16 October, 2025
Rationale: CNS-active drugs produce specific electroencephalographic changes. It is known that olanzapine produces an increase in the slow (delta and…
Read moreA two-compartment effect site model describes the Bispectral Index Score (BIS) after administration of propofol
Thursday 16 October, 2025
Objectives: Different estimates of the rate constant for the effect-site distribution (ke0) of propofol have been reported, depending on the…
Read moreModeling of Pain Intensity Measured on a Visual Analogue Scale and Informative Dropout in a Dental Pain Model after Naproxcinod and Naproxen Administration
Thursday 16 October, 2025
Objectives: The objective of this model was to describe the pain intensity (PI) and dropout due to request of rescue…
Read moreExtrapolation from preclinical PKPD data to clinical response, Application to a new antiepileptic medication (drug X)
Thursday 16 October, 2025
Objectives: To predict clinically relevant doses of a new antiepileptic drug from preclinical data based on PKPD modelling. Material and…
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