Poster: Applications- CNS Archives - Page 9 of 9 - PAGE Meeting (Population Approach Group Europe)

Exposure-Response Analysis of Longitudinal Adverse Event Data.

Thursday 16 October, 2025

Objectives: To describe the pregabalin-exposure and dizziness (adverse event) relationship in patients treated for Generalized Anxiety Disorder (GAD). Methods: A…

Comparision of Pregabalin and Gabapentin Pharmacodynamics in Patients with Refractory Partial Seizures.

Thursday 16 October, 2025

PDF of poster Objective: To compare the dose-response (seizure frequency) relationship of pregabalin and gabapentin add-on treatment in patients with…

Population Kinetic Pharmacodynamic and Logistic Regression Analysis of Intravenous Morphine Titration in Immediate Postoperative Period

Thursday 16 October, 2025

Objectives: Intravenous morphine titration has currently become the gold standard for pain management. However, concerns over accurate morphine titration adapted…

Analysing Raw Count data from an In Vitro Target Occupancy Assay to Select Doses for Human Safety/Tolerability Trial

Thursday 16 October, 2025

Introduction: Compound A is being developed to treat chronic pain in conditions such as osteoarthritis. As concentration effect relationship obtained…

Model-Based Analysis of a Longitudinal Binary Response as the Primary Analysis for a Phase II Study in Migraine Prophylaxis.

Thursday 16 October, 2025

Objectives: The objective was to design and evaluate a phase II proof of concept/dose-response study in Migraine Prophylaxis, exploiting the…

Integrated analysis of Human PET data across multiple brain regions and receptors to make inferences from limited data.

Thursday 16 October, 2025

Objectives: To estimate the concentration – receptor occupancy relationship for the main target brain receptor (R1) for centrally acting drugs…

Modeling and Simulation to Integrate Efficacy and Safety Data Following Full Development: a Case Study in Schizophrenia and Bipolar Disorder

Thursday 16 October, 2025

Objectives: While modeling and simulation is an excellent tool to quantitatively inform decision making in early clinical development phases, there…