Thursday 16 October, 2025
Objectives: This study aimed to characterize the pharmacokinetic-pharmacodynamic (PKPD) relationship between plasma concentrations, inhibition of TXB2 and PGE2 synthesis, and…
Read morePoster: Applications- CNS
The assessment of convulsion risk: a translational PK/PD modelling approach
Thursday 16 October, 2025
Objectives: Among the different central effects monitored during preclinical safety studies, convulsions are the one of the most concerning. After…
Read moreMixed Effects Markov Models for Modelling Sleep in Insomniac Patients Treated with Placebo in a 28 Days Trial: Emphasis on the Break Points Selection
Thursday 16 October, 2025
Objectives: A Mixed Effect Markov Model has been proposed in order to characterize the time course of sleep stage transitions…
Read moreA mechanism-based pharmacokinetic-pharmacodynamic model of the time-course of prolactin following antipsychotic drug treatment
Thursday 16 October, 2025
PDF of poster Objective: Antipsychotic drugs interact with dopamine receptors and can cause release of prolactin into the circulation which…
Read moreEstimation of occupancy and radioligand kinetics in the CNS from PET-data in the absence of a reference region.
Thursday 16 October, 2025
Objectives: With traditional methods calculation of occupancy is based on the specific uptake (binding potential) estimated individually from each PET-measurement….
Read morePopulation modeling of the relationship between ropinirole systemic exposure and efficacy in Parkinson’s disease
Thursday 16 October, 2025
Objective: Ropinirole is a nonergoline dopamine D2 agonist used for the treatment of Parkinson's disease. The objective of this work…
Read moreConcentration-Response Modelling of Adjunctive Lamotrigine Extended-Release for Primary Generalised Tonic-Clonic Seizures
Thursday 16 October, 2025
Background: Lamotrigine (LTG) immediate-release (IR) is indicated for several seizure types, including partial seizures and Primary Generalised Tonic-Clonic (PGTC) seizures, in…
Read moreDisease System Analysis: Evaluate the structural properties and the physiological implications of an indirect physiologic response model describing the degenerative progression of Alzheimer’s disease using a closed-form solution
Thursday 16 October, 2025
Objectives: In a previous communication [1] a novel Disease System Analysis approach has been proposed to describe the degenerative process…
Read moreClinical and Genetic factors affecting Alzheimer’s disease progression in subjects on stable acetylcholinesterase inhibitor therapy: a comparison between mechanistic and empirical disease progression modelling approaches
Thursday 16 October, 2025
Objectives: The objectives of the analysis were to compare empirical and mechanistic AD progression models based on subjects on stable…
Read morePrediction of remifentanil metabolic ratio using sparse data collected during non-steady-state infusion with rapidly changing rate
Thursday 16 October, 2025
Objectives: Remifentanil (R), an analgesic, is metabolised by non-organ dependent blood and tissue non specific esterases, and has a short…
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