Thursday 16 October, 2025
Objectives: Both in-house and literature1data show that CRF-1 antagonists display differing degrees of insurmountable antagonism in standard competition binding assays….
Read morePoster: Applications- CNS
Optimal dosing of lidocaine for seizure control in preterm and term neonates using population pharmacokinetic modelling and simulation
Thursday 16 October, 2025
Objectives: Lidocaine is widely used around the world for different indications. It has anaesthetic, sedative, antiarrhythmic and anticonvulsive properties. The…
Read moreContinuous time Markov modelling of relapse sojourns for relapse-remitting multiple sclerosis patients
Thursday 16 October, 2025
Objectives: To develop an exposure-response model for the sojourns in either a relapse or remitting disease state in relapse-remitting multiple…
Read morePopulation Pharmacokinetics of Lurasidone in Healthy Subjects and Subjects with Schizophrenia
Thursday 16 October, 2025
Objectives: Population pharmacokinetic (PK) analysis was performed to characterize lurasidone concentration-time profiles in healthy subjects and subjects with schizophrenia. Effects…
Read moreExternal validation of pharmacokinetic population model of alfentanil in obese patients.
Thursday 16 October, 2025
Objectives: Alfentanil is a short-acting opioid commonly used in anesthesia with a target-controlled infusion (TCI). This method uses a model…
Read morePopulation pharmacokinetics of carbamazepine in Iranian epileptic and manic patients
Thursday 16 October, 2025
Objectives:The aim of the present study was to develop a population pharmacokinetic model of carbamazepine from routine therapeutic drug monitoring…
Read moreExternal Validation of the Population Models for Carbamazepine Pharmacokinetics and the Individualizing Carbamazepine Dosage Regimen Procedure
Thursday 16 October, 2025
Objectives: The objective of external validation is to examine whether the model can equally describe a new data set, which…
Read moreImpact of Seizures and Efflux Mechanisms on the Biophase Kinetics and CNS Effects of Anticonvulsant Drugs
Thursday 16 October, 2025
Background: Several classes of efflux transporters are present at the blood-brain barrier (BBB). They are considered to act in tandem…
Read moreEvaluation of a Mechanism-Based Pharmacokinetic-Pharmacodynamic Model for D2 Receptor Occupancy of Olanzapine in Rats
Thursday 16 October, 2025
Objective: Two structurally different mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models were developed to predict the time course of dopamine receptor occupancy (D2RO)…
Read moreThe pharmacodynamics of isoflurane in children using Bispectral index and composite auditory evoked potentials
Thursday 16 October, 2025
Objectives: Bispectral index (BIS), derived from the electroencephalography (EEG), and the composite A-line autoregressive index (cAAI), derived from both the…
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