Thursday 16 October, 2025
PDF of poster Objectives: Brain distribution can be described with respect to the rate and extent of equilibration of a…
Read morePoster: Applications- CNS
Population pharmacokinetics of the new antiepileptic drug brivaracetam
Thursday 16 October, 2025
PDF of posterObjectives: Characterization of population pharmacokinetics of the new antiepileptic drug brivaracetam (ucb 34714) in healthy and epileptic adult…
Read moreUsing an Innovative Design in Behavioural Pharmacology Studies Saves Money and Animal Lives
Thursday 16 October, 2025
Objectives: Results from pre-clinical efficacy studies are of importance for many decisions in drug development. Being used to estimate active…
Read moreTransit Compartment Model Useful for Describing Absorption of Quetiapine XR and IR
Thursday 16 October, 2025
Objectives: Quetiapine fumarate is an atypical antipsychotic that has demonstrated efficacy in patients with schizophrenia, bipolar mania, bipolar depression, major depressive…
Read moreComparing treatment effect in depression trials: Mixed Model for Repeated Measures vs Linear Mixed Model
Thursday 16 October, 2025
Objectives: It is a well known fact that depression trials may fail in 50% of the cases even if effective…
Read moreNon-Linear Mixed Effects PK/PD Modelling of Acute Autoinhibitory Feedback Effects of Escitalopram (ESC) on Extracellular Serotonin (5-HT) Levels in Rat Brain
Thursday 16 October, 2025
Objectives: To characterise the PK/PD relationships including inter-individual variability (IIV) of ESC-induced 5‑HT response after acute administration to rats. A…
Read moreClinical trial simulations using a stroke disease progression model
Thursday 16 October, 2025
Background: Combined categorical-continuous models such as the stroke disease progression models [1-3] are of particular use where data are relatively…
Read moreModelling Sleep Using Markov Mixed Effects Models
Thursday 16 October, 2025
Objectives: To characterize the time course of sleep stages and the concentration-effect relationship of Drug X relative to placebo and…
Read moreA sparse sample PK & PKPD approach to estimate the time course of antipsychotic-induced D2 occupancy
Thursday 16 October, 2025
Background: Blockade of dopamine D2 receptors (D2RO) is a common feature of all antipsychotics (AP) and is a predictor of…
Read morePopulation pharmacokinetic modelling of pimozide and its relation to CYP2D6 genotype.
Thursday 16 October, 2025
Background: Pimozide is a dopamine receptor antagonist used to treat obsessive compulsive disorder associated with Tourette's syndrome. In humans, pimozide…
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