Thursday 16 October, 2025
Objectives: Therapeutic drug monitoring may improve the efficacy and safety of Voriconazole (VRC), a novel antifungal agent. However, the optimal…
Read morePoster: Applications- Anti-infectives
Influence of Rifampin Pharmacokinetic Variability on Antibacterial Effect and Prevention of Resistance in Pulmonary Tuberculosis: a Simulation Study
Thursday 16 October, 2025
Objectives: The pharmacokinetic-pharmacodynamic (PK-PD) relationships of rifampin (RIF) are a key issue in tuberculosis (TB) treatment. Both Mycobacterium tuberculosis (MTB)…
Read moreA Population Pharmacokinetic Study of Plasma and Intrapulmonary Concentrations of Rifampin
Thursday 16 October, 2025
Objectives: In pulmonary tuberculosis (TB), Mycobacterium tuberculosis (MTB) is both extracellular and intracellular. Rifampin (RIF) is probably the most important…
Read moreNevirapine – Population pharmacokinetic model building and simulation for mothers and newborns
Thursday 16 October, 2025
Objectives: Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor, is used as single-dose prophylaxis (mother: 200 mg tablet during labor, newborn:…
Read morePopulation Pharmacokinetic Model Building for Mothers and Newborns using Additional Information from a Different Nevirapine Dataset
Thursday 16 October, 2025
Objectives: Risk of HIV transmission from mother to newborn could be reduced by prophylaxis of nevirapine (PMTCT). 62 HIV-1 mothers…
Read morePopulation pharmacokinetic model development and evaluation after nevirapine administration to mothers and newborns
Thursday 16 October, 2025
Objectives: To reduce the risk of HIV transmission in resourced-limited areas a single oral dose of nevirapine (NVP), a non-nucleoside…
Read morePopulation analysis of plasma and intracellular pharmacokinetics of indinavir in HIV-1 infected patients with a stable antiretroviral therapy
Thursday 16 October, 2025
Objectives: Indinavir is a HIV protease inhibitor whom activity is intracellular. However, only few studies with measurements of intracellular indinavir…
Read morePopulation pharmacokinetic models for lamivudine and nevirapine to assess drug concentrations obtained during therapeutic drug monitoring
Thursday 16 October, 2025
Background and aims: Nucleoside reverse transcriptase inhibitors (NRTIs), the backbone of combined antiretroviral therapy (cART) in resource-limited countries, are not…
Read moreEffect of rifampicin-based antitubercular therapy and cotrimoxazole on the population pharmacokinetics of stavudine (d4T) in HIV-1 infected patients
Thursday 16 October, 2025
Objectives: The coadministration of antiretroviral and antitubercular therapy is known to result in drug-drug interactions due primarily to the induction of…
Read morePopulation Pharmacokinetics of Ganciclovir Following Oral Administration of its Prodrug Valganciclovir in Pediatric Renal Transplant Patients
Thursday 16 October, 2025
Introduction: Valganciclovir, the ester of ganciclovir and L-valine, is a prodrug of ganciclovir with improved oral absorption. It is well…
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