Thursday 16 October, 2025
Objectives: To describe the population pharmacokinetics (PPK) for artesunate (ART) and its active metabolite dihydroartesunate (DHA) following the administration of…
Read morePoster: Applications- Anti-infectives
High-dose amoxicillin pharmacokinetics (PK) and pharmacodynamics (PD) in children
Thursday 16 October, 2025
Objectives: We are unaware of any published PK data addressing oral amoxicillin (amox) dosages >25 mg/kg in children. Since amox…
Read moreVoriconazole Population Pharmacokinetics and Pharmacodynamics in Children
Thursday 16 October, 2025
Objectives: Published voriconazole pharmacokinetic (PK) and pharmacodynamic (PD) data are limited in children and adolescents and differ from adults. We…
Read morePopulation Kinetics and Dynamics of Lopinavir in HIV-Infected Children
Thursday 16 October, 2025
Objectives: To develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model of lopinavir (LPV) in HIV-infected children. Methods: Blood samples…
Read morePopulation Pharmacokinetics of Efavirenz and MDR-1, CY2B6, and CYP3A5 Polymorphisms
Thursday 16 October, 2025
Objectives: Efavirenz, an antiretroviral drug metabolized by polymorphic enzymes, exhibits between-subject pharmacokinetic variability causing varied clinical response. Lower and higher…
Read moreRelationship Between a PK/PD Parameter and Therapeutic Response of Ceftobiprole in Patients with Complicate Skin and Skin Structure Infection
Thursday 16 October, 2025
Objectives: Ceftobiprole is an investigational cephalosporin with activity against Gram-negative and Gram-positive pathogens, including methicillin-resistant staphylococci. Two phase 3 studies…
Read morePopulation pharmacokinetics of AZT and its active metabolite AZT-TP in HIV patients: joint modelling and design optimisation
Thursday 16 October, 2025
Objectives: To determine a joint pharmacokinetic (PK) population model of azidothymidine (AZT) and its active metabolite AZT-TP in HIV infected…
Read moreSimulation and development of a netilmicin extended dosing regimen for extremely premature neonates.
Thursday 16 October, 2025
Objectives: To develop an optimal extended dosing regimen for netilmicin in neonates. Methods: A retrospective chart review was performed for…
Read moreParallel first order and mixed order elimination of pyrazinamide in South African patients with tuberculosis
Thursday 16 October, 2025
Background: An earlier zero-order input model with first order elimination of pyrazinamide[1] poorly described absorption in a new cohort of…
Read moreSimultaneous Therapeutic Drug Monitoring Of Amikacin And Beta-Lactams In Intensive Care Unit Patients With Severe Sepsis Or Septic Shock Without Beta-Lactam Serum Concentration Monitoring
Thursday 16 October, 2025
Background: Associations of aminoglycosides and β-lactams are the most used treatment in intensive care unit (ICU) patients with severe sepsis…
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