According to the defined statistical model for inter-individual variability (example CLi = CL + ηi where i denotes the ith…

Read more

Popkan is a PC package designed to implement Bayesian techniques for the analysis of population pharmacokinetics data based on a…

Read more

Introduction: P-Pharm is a comprehensive software package for population pharmacokinetic-pharmacodynamic data modeling. P-Pharm has been developed alongside the latest technology…

Read more

At last year’s American Statistical Association’s meeting in Boston an organised session compared various approaches to population pharmacokinetic analyses, basing…

Read more

The Gibbs sampler is a computer-based algorithm for exploring posterior probability distributions in complex modelling situations. Observations are simulated from…

Read more

Two simulated population pharmacokinetic data sets were generated in order to compare and evaluate the robustness of different population methods….

Read more

A program was written implementing the EM algorithm of Dempster and Laird. Essentially the EM algorithm separates the structural estimation…

Read more

A physiological toxicokinetic model was used to describe the distribution and metabolism of tetrachloroethylene (TCE) in a human population. Data…

Read more

The authors of the recent ICH Draft Tripartite Guidelines on “Dose Response Information to Support Drug Registration” while stressing the…

Read more

Currently, there is increasing focus on integration of pharmacokinetic/pharmacodynamic (PK/PD) studies and modeling into drug development. Strategies involving specifically nonlinear…

Read more