Population pharmacokinetic analysis of drugs belonging to the class of organic ions may use very similar physiologic models. Because of…
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Multicenter Study Of Amikacyn PK From Patients Under TDM.
Since 1988, the USC.PACK softwares have been used for TDM of Amikacyn, in various French Hospitals (Lyon, Marseille, Le Mans,…
Read morePopulation Analysis Of The Kinetics Of Lithium Using NPML And Evaluation Of The Estimated Characteristics On A Group Of Patients Regimen
A population analysis of the kinetics of lithium is performed on a set of experimental and observational data, composed of…
Read moreOptimal Design In Population Analysis Including Bayesian Aspects
It is well known in nonlinear regression that the accuracy of the estimator is related to the experimental design. The…
Read moreTutorial: Optimal design for population analysis
Introduction General considerations on the accuracy of estimators in nonlinear regression, on the Fisher information matrix and D-optimality. Extension to…
Read morePoints To Consider When Presenting Population Analysis To Regulatory Autorities.
The presentation will be based on points to consider when submitting population analysis to regulatory authorities within a New Drug…
Read moreInternational Harmonisation Of Guidelines On Studies In Special Patient Populations
An overview will be given of the actual status and ongoing talks to come to an harmonised guideline on studies…
Read morePopulation Analysis Of A Slow-Release Nitrate
Data from 10 separate studies (4 experimental studies in volunteers (n=50) and 6 observational studies in patients (n=142)) who received…
Read moreIllustration Population Kinetics and Population Dynamics analysis via Gibbs Sampler
Population modelling is widely used in Biometrical growth curve analysis, (see for example Berkey 1982), in pharmacokinetics and pharmacodynamic studies…
Read moreNONMEM Running On A PC Workstation : Installation And Use In A Clinical Pharmacy Department
I) Why NONMEM On Such A Configuration, And What For ? Unquestionable software for PK analysis of sparse datas in…
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