Thursday 16 October, 2025
Modeling, in the context of drug development, means the application of theory (science) as opposed to, or in addition to,…
Read moreoral presentation
Review of methods
Thursday 16 October, 2025
Population models contain large numbers of parameters and, for each of the individuals, a nonlinear relationship between observed concentrations and…
Read moreExperience With NONMEM For Analysis Of Intravenous Infusion Data With Two And Three Compartment Models
Thursday 16 October, 2025
Pharmaceutical industry gives more and more focus on the implementation and evaluation of data analysis methodology for population approach, during…
Read moreExperience With NONMEM Applied To Phase III Clinical Trial With Many Covariates
Thursday 16 October, 2025
Pharmacokinetic modeling is widely used in phase 1 clinical trials, in order to explain the variability between the dose-concentration relationships….
Read moreExperience With Nonmem: Population Pharmacokinetics Of Propofol
Thursday 16 October, 2025
Introduction: Population pharmacokinetics is an important tool in anaesthesiology, it allows to estimate not only the mean pharmacokinetic parameters of…
Read morePopulation Pharmacokinetics of Vancomycin in neonates
Thursday 16 October, 2025
Vancomycin is a glycopeptide antibiotic which is active against Gram +ve organisms. As many of these organisms are becoming resistant…
Read morePopulation Kinetics of Gentamicin in Neonates
Thursday 16 October, 2025
Summary : A population kinetic analysis was carried out on sparse Gentamicin (GE) data collected from 469 neonates as part…
Read moreRisperidone Dose-Proportionality In Psychotic Patients Using A Population Pharmacokinetic Analysis
Thursday 16 October, 2025
Only limited doses of the antipsychotic risperidone can be tolerated when given acutely. Single-dose pharmacokinetic studies were restricted to oral…
Read morePitfalls in Retrospective Analysis in Search of Concentration-Effect Relationships
Thursday 16 October, 2025
Retrospective population analysis in search of concentration-effect (C-E) relationships in data from randomized, concentration-monitored, dose-response trials has been advocated (1,2)….
Read moreThree New Residual Error Models For Population PK/PD Analyses
Thursday 16 October, 2025
Residual error models, traditionally used in population pharmacokinetic analyses, have been developed as if all sources of error have the…
Read more