Program - PAGE Meeting (Population Approach Group Europe)

June 2, 2026

12:00 - 18:00

Registration at the Conference Venue
19:30 - 21:00

Opening Ceremony, welcome reception

June 3, 2026

08:00 - 08:45

Registrations
08:45 - 08:55

Welcome & Introduction

Robert Likic & Oscar Della Pasqua
09:00 - 09:40

Keynote: Preclinical/Translational Modelling

Gauri Rao & Zinnia P Parra-Guillen
09:00 - 09:40

Iñaki F Trocóniz

- Insights into Preclinical and Translational Challenges in Oncology Model-Informed Drug Development
09:40 - 09:50

Q&A
09:50 - 10:30

Preclinical Modelling

Chairs: Gauri Rao & Zinnia P Parra-Guillen
09:50 - 10:10

Miriam Happ

- A FAIR combination: guiding development of a novel immunomodulatory-antibiotic combination therapy using an integrative PKPD framework based on multi-source preclinical data
10:10 - 10:30

Adrien Mitard de Girardier

- Modelling jointly viral dynamic and fever during H1N1 infections in non-human primates
10:30 - 12:00

Coffee break, Poster and Software Demonstration I
12:00 - 13:00

Translational Frameworks

Luca Marchetti & Akash Khandelwal
12:00 - 12:20

Elena Maria Tosca

- Clip: a Translational PK/PD Tool to Predict ORR in Solid Tumors using PDX Data
12:20 - 12:40

Julia Stolk

- Time matters: Predicting gemcitabine exposure in the pediatric brain with diffuse midline glioma using LeiCNS-PK3.0
12:40 - 13:00

Denis Menshykau

- From mother to newborn: pregnancy PBPK-PD modeling for rozanolixizumab
13:00 - 14:30

Lunch
14:30 - 15:20

Tutorial: Model-based Meta Analysis

Thomas Dumortier & Camille Vong
14:30 - 15:20

Monica Simeoni & Matt Zierhut

- Methodological considerations in Model-based Meta-Analysis– Concepts, applications, and implementation
15:20 - 16:50

Coffee break, Poster & Software demonstration II
16:50 - 17:50

Advancing biologics and novel modalities

Charlotte Kloft & Lena Friberg
16:50 - 17:10

Jannik Vollmer

- Anatomy-level pharmacokinetics of an intrathecally administered ASO
17:10 - 17:30

Nina Beutling

- Model-Based Quantification of Soluble CEACAM5 Impact on the Pharmacokinetics of A T-Cell Bispecific Antibody to Inform Clinical Decisions
17:30 - 17:50

Daniel Bending

- Structural Identifiability Analysis of Ghost Payload Dynamics in Antibody-Drug Conjugate Pharmacokinetic Models: A Minimal DAR2 Framework

June 4, 2026

08:30 - 09:50

Lewis Sheiner Student Session

Sylvie Retout, Elena Tosca, Brian Corrigan
08:30 - 08:55

Ludvig Jakobsson

- Modelling home-measured peak expiratory flow using a mixed-effects hidden Markov model: An alternative approach to quantifying treatment effects in asthma
08:55 - 09:20

Bhavatharini Arun

- Model-based approach to optimizing antibiotic therapy for central nervous system infections: integrating blood-brain barrier permeability, cerebrospinal fluid hydrodynamics, and site-specific drug exposure
09:20 - 09:45

Lucie Fayette

- New methods based on the Fisher Information Matrix for evaluation and optimisation of designs testing relevance of covariates in pharmacometrics
09:45 - 09:50

Presentation LBS awards
09:50 - 11:20

Coffee break, Poster & Software Demonstration
11:20 - 12:40

Stuart Beal Methodological Session

Gilbert Koch & Emmanuelle Comets
11:20 - 11:40

Niels Hendrickx

- New tests for trials evaluating disease-modifying treatment in very few patients using longitudinal data in Autosomal Recessive Cerebellar Ataxias
11:40 - 12:00

Alexander Janssen

- Gaussian Process Flows: Accurately characterising drug exposure and effects through Bayesian Inference over mechanistic models.
12:00 - 12:20

Melanie Prague

- Regularized estimation in high-dimensional mechanistic models: application to vaccine development
12:20 - 12:40

Malvina Marku

- Integration of mechanistic pharmacokinetic models with gene regulatory networks for early detection of resistance in Chronic Lymphocytic Leukaemia
12:40 - 13:40

Lunch
13:40 - 15:10

Coffee break, Poster & Software Demonstration IV
15:10 - 16:10

Informing Clinical Decisions: from methods to practice

Stefanie Hennig and Rob ter Heine
15:10 - 15:30

Laura B. Zwep

- Using copulas to quantify patient representation and model suitability in model-informed precision dosing
15:30 - 15:50

Daniel Jonker

- Quantitative systems pharmacology model for follicle development and oocyte retrieval during ovarian stimulation
15:50 - 16:10

Britta Steffens

- Translating pharmacometric modeling into global clinical practice: lessons learned from developing a scalable clinical decision support system for pediatric thyroid care
16:10 - 16:20

Preview PAGE2027
20:00 - 23:59

Social Event

June 5, 2026

09:30 - 10:30

Biomarkers to the rescue

Ana Ruiz & Marylore Chenel
09:30 - 09:50

Assil Merlaud

- Prognostic value of organ-specific tumor dynamics on overall survival across nine cancer types: a two-stage individual patient data meta-analysis of multilevel joint models
09:50 - 10:10

Thanakorn Vongjarudech

- Joint modeling of time to positivity (TTP), mycobacterium tuberculosis – molecular bacterial load assay (TB-MBLA), and PATHFAST TB LAM AG test: Quantifying inter-biomarker correlations and drug effects in pulmonary tuberculosis
10:10 - 10:30

Tom Chebassier

- Modeling expanded disability status scale trajectories and their association with serum neurofilament light chan in alemtuzumab-treatment relapsing remitting multiple sclerosis patients
10:30 - 10:40

Announcement ACoP&ISoP
10:40 - 11:25

Coffee break
11:25 - 12:45

ML to advance Pharmacometrics

James Lu & Coen van Hasselt
11:25 - 11:45

Zhe Li

- Identifiability-aware variational autoencoder for inference of NONLINEAR mixed effect models based on ordinary differential equations
11:45 - 12:05

Lorenzo Contento

- Early go/no-go decisions in clinical trials using a DeepNLME joint tumor growth dynamics and overall survival model
12:05 - 12:25

Romain Ferrara

- Large-language-model-guided discovery of population pharmacokinetic structural models:Evaluation across synthetic and real data
12:25 - 12:45

Ali Issa

- ConstrainNODE-PK: Constrained neural impulse-response population PK for trial simulation and regimen transfer without compartmental selection
12:45 - 12:55

Closing Remarks

Oscar Della Pasqua