5th Educational Pharmacometrics Summer Symposium (EPSS)
Date: Tuesday, June 2nd 2026
Time: Full‑day
Venue: Valamar President Hotel (Room: Tajan), near the PAGE venue
Description:
The fifth Educational Pharmacometrics Summer Symposium (EPSS) is a free one‑day event introducing pharmacometrics (PMx) and demonstrating its impact on model‑informed drug development and therapy individualisation.
The programme includes an introduction to PMx, its applications in preclinical and clinical drug development, and sessions on treatment optimisation and personalisation. Afternoon presentations will showcase selected student case studies, followed by a short collaborative group activity (programme).
The symposium is ideal for MSc/PhD students, postdocs, and anyone interested in PMx, including clinical pharmacists, clinicians, statisticians, mathematicians, and industry professionals.
Students and postdocs may submit PMx‑related abstracts (3,000-4,500 characters; may be identical to PAGE 2026 submissions) to EPSS2026@gmail.com. Abstract deadline is 3 May 2026.
The symposium is sponsored by Boehringer Ingelheim, Pharmetheus and University of Belgrade.
Participants: ~50
Fees: Free of charge
Register here (open until 3 May 2026)
PK/PD & QSP simulations with e-Campsis desktop
Date: Tuesday, June 2nd, 2026
Time: 1:00 pm – 5:00 pm
Venue: ROYAL HOTELS & RESORT, Kardinala Stepinca 31, Dubrovnik
Description:
Calvagone will be running a free half-day workshop on e-Campsis desktop, our brand-new application to set up and run PK/PD & QSP simulations locally on your computer.
During this hands-on workshop, participants will get access to the standalone e-Campsis desktop application and learn how to:
- Import a model from various sources (Campsis, model library, rxode, mlxtran, NONMEM)
- Set up a trial design manually in the interface or using the embedded trial design AI assistant
- Bootstrap covariates from an external source (e.g. NHANES)
- Explore what-if scenarios thanks to the built-in scenario creator
- Stratify and visualize the results with customizable plots
- Post-process results, derive key metrics and summary statistics, and generate report-ready tables in just a few clicks
- Overlay external data on top of simulations
Participants will get a 1-month trial license of e-Campsis Desktop and should bring their own laptop, with the tool and R-4.5.2 installed (instructions will be sent to registered participants 1 week before the course).
Fees: Free of charge:
Model-Based Meta-Analysis (MBMA): Concepts, Methodologies, and Hands-on Workshop
Date: Tuesday, June 2nd
Time: 8:00 – 17:00
Venue: Valamar President Hotel – Olipa 2
Description:
Attendees of this one-day workshop will learn about model-based meta-analysis (MBMA) – starting with the basic principles of meta-analysis and moving toward detailed applications of complex MBMA methodologies. Concepts will be explained using case studies, accompanied by detailed hands-on exercises based on Certara’s CODEx software platform, R scripts and real datasets
Some critical topics include:
- MBMA of binary and continuous data
- Dose-response relationships
- Longitudinal data
- Exploration of covariate effects
- Joint MBMA of multiple endpoints
- Methodological aspects
– Relative effect vs absolute outcome modeling
– Unstructured (nonparametric) placebo methodology
– Prognostic vs. predictive covariates
– Random effects and weighting of data
– Data transformations
Fees:
Cost: €250 Student / €500 non-student
For further information please email Matt Zierhut at matt.zierhut@certara.com.
Maximum of 30 participants
RsNLME: Writing population PK & PKPD models in PML and running them in R
Date: Tuesday, June 2nd 2026
Time: 09:00 – 17:00
Venue: Lopud room, Valamar Lacroma Hotel
Description:
This course is a unique opportunity to learn from Professor Stephen Duffull, a globally recognized pharmacometrician with more than 30 years of experience. Although he is widely known for his deep expertise in NONMEM and population PK/PD modelling, in this course, he will be teaching RsNLME, bringing the same rigor, quantitative insight, and modelling principles that have guided his work throughout his career. His ability to translate concepts across modelling platforms makes his instruction especially valuable for learners adopting RsNLME and with some prior knowledge of NONMEM.
The workshop is SOLD OUT!
Thank you for your interest!
1. Satellite Meeting Title: Mastering PBPK with PK-Sim®: Basics to DDI.
Date: Monday, June 1st, 2026
Time: 9:00 am – 5:00 pm
Venue: Valamar Lacroma Hotel, Dubrovnik, Croatia
Description:
ESQlabs is excited to present four Satellite Workshop options at PAGE!
Two full-day workshops will take place on June 1, followed by two additional full-day workshops on June 2. To get the most out of the experience, choose one workshop on Day 1 and another on Day 2, creating a comprehensive learning path and maximizing your time at PAGE.
The first part of this hands-on workshop, “Mastering PBPK with PK-Sim®: Basics to DDI” introduces you to the fundamentals of Physiologically Based Pharmacokinetic (PBPK) modelling using PK-Sim®, part of the open-source and freely available OSP Suite. This practical session focuses on learning by doing. You will build a PBPK model from scratch, explore the PK-Sim® interface, and learn to interpret key outputs.
The second part of the workshop will focus on how to simulate and evaluate drug-drug interaction (DDI) scenarios using PK-Sim®. You will gain practical experience setting up DDI simulations, applying qualified models, and assessing key interaction mechanisms to support regulatory-ready analyses.
To ensure maximum hands-on time, theoretical content will be kept concise and directly applicable.
At the end of the workshop, you will be able to:
- Build and run a simple PBPK model
- Perform sensitivity analysis and parameter optimization
- Interpret key outputs
- Set up a DDI simulation between 2 or more compounds using qualified models from the free public PK-Sim library
- Derive and interpret the DDI metrics to determine the DDI risk
Who Should Attend? Anyone with an interest in the capacities of PK-Sim® free software to explore basic PBPK modeling and PBPK modeling of DDI liabilities
Prerequisites: Basic knowledge of pharmacokinetics, PBPK, and principles of DDI.
Instructors: Dr. Carla Troisi and Dr. Ingrid Michon
The current prices reflect our early bird discount, valid until April 20.
The participation fee includes catering with a morning coffee break, lunch, and an afternoon coffee break (excluding VAT).
Seats are limited, so secure your spot early.
Early Bird Prices until 20/04:
- Industry: 400,00 €
- Academia/ Government: 250,00 €
- Students: 100,00 €
Regular Prices after 20/04:
- Industry: 500,00 €
- Academia/Government: 300,00 €
- Students: 150,00 €
Register Here: PAGE Day 1: Mastering PBPK with PK-Sim®: Basics to DDI. – ESQlabs GmbH
2. Satellite Meeting Title: R Workflows for advanced PBPK & QSP Modeling with {ospsuite}and {esqlabsR}
Date: Monday, June 1st, 2026
Time: 9:00 am – 5:00 pm
Venue: Valamar Lacroma Hotel, Dubrovnik, Croatia
Description:
During this intermediate workshop, “R Workflows for Advanced PBPK & QSP Modeling with {ospsuite} and {esqlabsR}”, participants will learn how to utilize the R package ecosystem of the OSPS to conduct M&S projects in R.
The workshop will start by introducing the basics of the {ospsuite} R package, covering topics such as:
- Changing model parameters
- Running simulations and processing simulation results
- Calculating PK parameters
- Running sensitivity analyses
- Creating standard figures
In the second part, attendees will learn how to conduct complex, regulatory-compliant M&S projects using the {esqlabsR} ecosystem and the ESQapp. This part will include:
- Defining simulation scenarios with traceable and reproducible parameterization
- Defining figures
- Performing advanced sensitivity analyses
- Creating reports with Quarto (R Markdown)
Prerequisites: This workshop assumes basic knowledge of the OSPS. Participants are expected to have prior experience with PK-Sim and/or MoBi. The workshop will not cover the basics of PBPK modeling with the OSPS.
Instructors: Pavel Balazki and Dr. Wilbert de Witte
The current prices reflect our early bird discount, valid until April 20.
The participation fee includes catering with a morning coffee break, lunch, and an afternoon coffee break (excluding VAT).
Seats are limited, so secure your spot early.
Early Bird Prices until 20/04:
- Industry: 400,00 €
- Academia/ Government: 250,00 €
- Students: 100,00 €
Regular Prices after 20/04:
- Industry: 500,00 €
- Academia/Government: 300,00 €
- Students: 150,00 €
Register Here: PAGE Day 1: R Workflows for advanced PBPK & QSP Modeling with {ospsuit – ESQlabs GmbH
3. Satellite Meeting Title: Physiologically Based Biopharmaceutics Modeling (PBBM) with PK-Sim® and MoBi® (OSP-Suite)
Date: Tuesday, June 2nd, 2026
Time: 9:00 am – 5:00 pm
Venue: Valamar Lacroma Hotel, Dubrovnik, Croatia
Description:
This intermediate workshop, PBBM with PK-Sim® and MoBi®, will present the principles and applications of physiologically based biopharmaceutics modeling (PBBM) and oral drug absorption with hands-on examples using PK-Sim®, MoBi®, the OSP-Suite, and R.
At the end of the workshop, you will be able to:
- Gain insight into the mechanistic absorption modeling with PK-Sim®.
- Apply PBBM to predict dissolution behavior and optimize drug formulations for improved oral absorption.
- Learn about the in vitro-in vivo correlation (IVIVC) concept and its significance in pharmaceutical development and regulatory applications.
- Explore methods and approaches for establishing IVIVC relationships to predict in vivo drug behavior from in vitro data.
- Understand the concepts of dissolution-safe space and virtual bioequivalence.
- Engage with hands-on exercises to get practical experience running Virtual Bioequivalence with PK-Sim® and R.
Who Should Attend? Pharmacometricians, clinical pharmacologists, and formulation scientists with an interest in exploring PBBM possibilities using the free OSP suite software
Prerequisite: basic knowledge in PK-Sim®, gained through hands-on experience or by attending the “Mastering PBPK with PK-Sim®” from Day 1 ESQlabs workshops at PAGE.
Instructors: Dr. Mariana Guimaraes Sa Correia and Dr. Stephan Schaller.
The current prices reflect our early bird discount, valid until April 20.
The participation fee includes catering with a morning coffee break, lunch, and an afternoon coffee break (excluding VAT).
Seats are limited, so secure your spot early.
Early Bird Prices until 20/04:
- Industry: 400,00 €
- Academia/ Government: 250,00 €
- Students: 100,00 €
Regular Prices after 20/04:
- Industry: 500,00 €
- Academia/Government: 300,00 €
- Students: 150,00 €
Register Here: PAGE Day 2: Physiologically Based Biopharmaceutics Modeling (PBBM) wit – ESQlabs GmbH
4. Satellite Meeting Title: Building Scalable PBPK – QSP Models
Date: Tuesday, June 2nd, 2026
Time: 9:00 am – 5:00 pm
Venue: Valamar Lacroma Hotel, Dubrovnik, Croatia
Description:
The revolutionary modularization approach introduced in V12 of the OSP Suite significantly enhances the flexibility, scalability, and efficiency of quantitative systems pharmacology (QSP) modeling and integrations with physiologically based PK (PBPK-QSP).
This full-day hands-on workshop, “Building Scalable PBPK-QSP Models”, will equip participants with the skills to leverage modular workflows in MoBi® to build, extend, and refine PBPK-QSP models like never before.
During this advanced workshop, attendees will start with a simple two-compartment model to grasp the fundamentals of modularization before diving into a real-world case study: modeling an ADC modality for tumor treatment.
In the second part of the workshop, participants will:
- Develop a PBPK model for the large molecule and small molecule payload.
- Modularization 1: Add a Target-Mediated Drug Disposition reaction network as a reaction extension module.
- Modularization 2: Add a tumor organ as a physiological extension module.
- Modularization 3: Implement a pharmacodynamic effect extension module to simulate tumor growth inhibition.
- Work with separate modules to demonstrate how modular workflows streamline model management, reuse, and extension.
Attendees will master the new modular approach in MoBi®, learning how to efficiently build and manage complex models in a structured way. While automated model qualification will be touched upon as an outlook, the focus will be on hands-on modeling and modularization techniques that enhance collaboration, transparency, and reusability in PBPK-QSP modeling.
At the end of the workshop, you will be able to:
- Understand the modularization in OSP Suite V12
- Add new organs to PBPK models seamlessly
- Develop effect models as independent modules
- Model tumor treatment and large molecules with modular PBPK-QSP workflows
Who Should Attend? This workshop is ideal for PBPK/QSP modelers, clinical pharmacologists, and researchers looking to enhance their mechanistic modeling workflows using the latest innovations in MoBi® and OSP Suite V12. Whether you’re new to OSP Suite or an experienced user, you’ll leave with practical skills to create modular, scalable, and reusable models for drug development and translational research.
Prerequisite: basic knowledge in PK-Sim®, gained through hands-on experience or by attending the “Mastering PBPK with PK-Sim®” from Day 1 ESQlabs workshops at PAGE.
Instructors: Dr. Wilbert de Witte and Tatiana Zasedateleva .
The current prices reflect our early bird discount, valid until April 20.
The participation fee includes catering with a morning coffee break, lunch, and an afternoon coffee break (excluding VAT).
Seats are limited, so secure your spot early.
Early Bird Prices until 20/04:
- Industry: 400,00 €
- Academia/ Government: 250,00 €
- Students: 100,00 €
Regular Prices after 20/04:
- Industry: 500,00 €
- Academia/Government: 300,00 €
- Students: 150,00 €
Register Here: PAGE Day 2: Building Scalable PBPK – QSP Models – ESQlabs GmbH
A spinoff company of the National and Kapodistrian University
of Athens (NKUA) on Software and Pharmaceuticals
Renaissance in Pharmacokinetics: Finite-Time and Fractal Tools for Drug Development and Population Analysis
Date: Tuesday, June 2nd, 2026
Time: 09:00 – 14:15
Venue: Valamar Lacroma Hotel
This hybrid seminar (blending in-person participation with a virtual audience) is intended for academics, students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations.
Description:
In the field of oral drug absorption, PBPK studies and Population analyses rely on first-order absorption kinetics, which implies that drug absorption runs for infinite time. This is physiologically impossible.
In the last seven years or so, we have provided conclusive evidence drug absorption follows zero- order kinetics (single or multiple) because of the high blood flow rate in the portal vein, Fig. 1.
Fig .1. The small intestine is modeled as a homogeneous cylindrical tube of length L, radius R and the volumetric flow rate, Q. The tube is surrounded by the portal vein indicating the high blood flow rate (Iranpour et al., 2016) towards the liver maintaining sink conditions for the drug molecules in solution (denoted as circles) transfer. (European Journal of Pharmaceutical Sciences (2026), doi: https://doi.org/10.1016/j.ejps.2026 )
This session will be hosted by Panos Macheras, PhD, (CEO F.A.T. Labs).
Presentations will be by Woojin Jung, PhD (CHA University, S.Korea); Sergio Sanchez-Herrero (Empresarios Agrupados, Spain), Carlos Perez (Pop Modeling Director, F.A.T. Labs) and Nikos Alimpertis, MSc (NKUA Pharmaceutical Technology).
Fees:
- €40 (full-time student/post-doc)
- €80 (full-time academic, regulatory)
- €120 (industry)
New and Advanced Features of NONMEM 7.6 In person Workshop
Date: Monday, June 1st
Time: 09:00-17:00
Venue: Valamar Lacroma Hotel
Description:
A one-day NONMEM 7.6 course will be presented by ICON at the PAGE 2026 Conference. This one-day, in-person, workshop will cover the description and use of features in NONMEM 7. Workshop attendees will be instructed how to specify gradient precision and how to use the FAST algorithm (new in NM 7.4) for FOCE and will also be instructed on how to use the Monte Carlo importance sampling, stochastic approximation expectation-maximization methods, and full Bayesian methods such as Gibbs sampling and Hamiltonian no-U turn sampling (new in NM 7.4). Parallel computing and dynamic memory allocation for efficient memory usage will also be described as well as symbolic references to thetas, etas, and sigmas, priors to sigmas, MonteCarlo search algorithms to improve FOCE estimation, built-in individual weighted residuals, bootstrap tools for simulation, and automatic stabilization against numerical exceptions. Also, learn to use new abbreviated code features for easier modeling of inter-occasion variability, modelling additional mixed effects levels for grouping individuals, such as inter-clinical site variability, and using the DO loop feature in abbreviated code, useful for handling multiple bolus doses in models that use the analytical absorption function for multiple transit compartments. New in NONMEM 7.5: Optimal clinical design and evaluation tool is available, as well as delay differential equation solvers.
Fees: (payment is expected via credit card upon receipt of quote)
Industry $600,00
Academia/Government $300,00
Students $150,00
Contact IDSSOFTWARE@iconplc.com for details and registrations!
Find the Agenda here: ICON_New and Advanced Features of NONMEN Workshop_Agenda_PAGE2026
AI/ML in Pharmacometrics: Hands-On Workshop and Regulatory Panel
Date: Tuesday, June 2nd
Time: 08:30 – 16:30
Venue: Olipa 3 room, Valamar President Hotel
Description:
Artificial Intelligence and Machine Learning (AI/ML) are rapidly transforming pharmacometrics, offering new tools for model development, covariate selection, and data analysis. Organized by the AI/ML Special Interest Group (SIG) under ISoP (https://www.isop.org/special-interest-groups/aiml-sig), this interactive satellite workshop provides both an overview and hands-on experience with AI-assisted coding tools and open-source ML frameworks in R and Julia, alongside a panel discussion of regulatory considerations and best practices. The workshop includes:
- Hands-on demonstration of GenAI coding assistants (e.g., GitHub Copilot)
- Live open-source coding exercises (Neural ODEs, ML-based covariate selection, Explainable AI)
- Panel discussion with regulatory and industry experts
- Networking and community building
Participants must bring their own laptop and have a Github account
Fees:
- Industry participants: €200
- Academic participants: €150
- Students: €70 (a scan of their current student card will be required)
- ISoP members receive a 20% discount
Cancellation Policy
- Registration fees are non-refundable
- Substitutions are permitted (please notify organizers in advance)
Registration includes workshop participation, mid-morning coffee, light lunch, and afternoon refreshments. Due to limited capacity (6–12 participants), registration is confirmed only upon payment.
Seats are allocated on a first-come, first-served basis.
For questions, please contact the ISoP AI/ML SIG at aiml_sig@isop.org
Collaboration and Automated Testing Workflows for Software Development in MATLAB & SimBiology
Date: Tuesday, June 2nd, 2026
Time: 9am-1pm EEST
Venue: Royal Hotels & Resort, Kardinala Stepinca 31, 20000 Dubrovnik, Croatia
Description:
As more SimBiology users collaborate on building models and writing customized code, modern software development practices like version control, automated testing, and CI/CD (continuous integration / continuous deployment) are becoming essential for ensuring reliability and reproducibility.
In this hands-on workshop, you will learn how to apply best practices for collaborative model development and analysis workflows that are automatically tested. Using a web application for simulating a SimBiology model, we will demonstrate how Git-based workflows, the MATLAB Build Tool, and CI systems such as GitHub Actions and GitLab CI can help speed up development by allowing multiple team members to contribute to the same project, while also maintaining code quality by automatically ensuring that new code contributions do not break the existing codebase.
What you will learn:
- How to use automated testing to detect bugs early and prevent regressions after code changes
- How to run MATLAB and SimBiology in CI systems
- How to effectively use the MATLAB Build Tool to enforce consistent build sequences and skip unnecessarily rebuilds
- How to compare SimBiology models developed by collaborators and resolve merge conflicts efficiently.
Fees: Free of charge
Prerequisite: Knowledge of MATLAB and SimBiology is required. Basic knowledge of Git workflow would be beneficial.
Beyond the Hype: Practical Applications of LLMs in Pharmacometrics
Date: Tuesday, June 2nd
Time: 13:00-15:30 (CEST)
Venue: Hotel More in Dubrovnik, Kardinala Stepinca 33, 20000 Dubrovnik, Hrvatska
Description: While Generative AI promises to revolutionize drug development, the transition from ‘chatting with a bot’ to a validated pharmacometrics workflow remains a significant hurdle. How do we harness these tools to improve efficiency, without compromising scientific integrity or regulatory and data governance concerns?
In this two-hour workshop, MetrumRG will share a practical, human-in-the-loop framework for integrating large language models (LLMs) into pharmacometrics. We will briefly review the evolving regulatory landscape, and discuss how to assess and mitigate the risk of using LLMs in a regulated environment. The core of the workshop then focuses on demonstrating how LLMs, when used with a consistent ‘backbone’ of standardized tools, can increase both efficiency and quality throughout the analysis, from data preparation to reporting.
Attendees are expected to have a basic understanding of the capabilities of LLMs prior to the workshop. They will leave with a clear, actionable approach for incorporating LLMs into their work, along with a preview of how these capabilities are being embedded into modern platforms by the Metworx team.
This session will be hosted during the PAGE Meeting in Dubrovnik, Croatia by Seth Green, M.S., Director of Data Science and Sam Callisto, Ph.D., Senior Scientist II.
Max participation: 65 total seats
Fees:
€20 (full-time student/post-doc)
Note: use code STUDENT20 at checkout.
€40 (full-time academic, regulatory)
Note: use code ACADEMIC40 at checkout.
€80 (industry)
Model-informed approach for safe starting dose estimation in First-in-Human trials
Date: Monday, June 1st 2026
Time: 09:00-17:00, lunch 13:00-14:00 (total: 7 hours)
Venue: Valamar Lacroma Hotel, Meeting room: Divona 2
Target audience:
Pharmacometricians, modeling scientists and students who seek to gain in-depth knowledge of bispecific antibody drug development, with emphasis on pharmacokinetics, pharmacodynamics and practical skills in quantitative systems pharmacology modeling
Annotation:
Join us for a one-day workshop hosted by M&S Decisions, to focus on translational mechanistic modeling in support of First-in-Human (FiH) safe starting dose selection.
The topic addressed in the workshop is of utmost importance, given the intricacies in pharmacokinetics and pharmacodynamics, and the corresponding unique safety challenges inherent to this multi-component therapeutic modality. The mechanistic modeling approach presented, which we will examine in a practical, hands-on manner, represents a must-have element in CTA/IND submissions.
The case examples which we will be focusing on during the workshop are based on the actual modeling applications in the development of T cell engagers (TCE) and other types of bispecific antibodies, although the overall methodology becomes generally for other types of novel multi-component therapeutics, such as autologous and allogenic cell therapies, antibody-drug and -oligo conjugates, targeted lipid or polymer nanoparticles with encapsulated drug, PROTACs etc.
In fact, our session will take participants through various modeling approaches, from a more empirically driven workflow to estimate FiH starting dose using MABEL criteria, to a mechanistically oriented translational approach using a quantitative systems pharmacology (QSP) modeling workflow. Work will be held on an integrative cloud ecosystem, “Simurg”, and a set of packages from the R programming environment.
What you will learn
The workshop covers the following key elements of FiH dose selection for bispecific antibodies:
- Therapeutic utility and challenges in the development of complex, multi-component biologics and cellular therapies;
- Implementation of FiH dose selection based on minimal anticipated biological effect level (MABEL) criteria;
- Model-based analysis of in vitro cytotoxicity data, while accommodating for diverse experimental conditions (incubation time, E:T ratio, various cell lines, etc.) using conventional fitting algorithms (i.e., NONMEM, Monolix, nlmixr) implemented in Simurg ecosystem;
- Development of a translational QSP model to predict exposure-efficacy and exposure-safety relationships in patients – from exploratory data analysis to advanced diagnostics;
- Generation of virtual patient populations which take into account variabilities in PK and in diverse disease states and immunological conditions;
- Implementation of model-informed selection of pharmacologically active and safe starting doses for bispecific antibodies, based on a case study with T cell engagers (TCE);
- Regulatory requirements for inclusion of the MIDD approaches to support CTA/IND applications.
Mentors:
Victoria Kulesh, Dr. Victor Sokolov, Dr. Alina Volkova, Dr. Yuri Kosinky, Dr. Kirill Peskov
Fees (excl. VAT):
– Industry: €500 (€250 online)
– Academics: €250 (€100 online)
– Students: €150 (free online)
25 offline seats + 25 online seats
Technical requirements:
Laptop and functional browser.
AI-Powered Pharmacometrics Workflows: From Routine Tasks to App Development
Date: Friday, 5 June 2026
Time: 10:00-16:00 (6 hours)
Venue: Valamar Argosy Hotel. Meeting room: Karaka
Target audience:
Pharmacometricians, modeling scientists and students who aim to learn artificial intelligence (AI) applications in pharmacometrics (PMx) and harness AI for acceleration of scientific research via AI-assisted data mining and processing as well as creation of R-based modeling workflows and building up-to-date programming interfaces.
Annotation:
Join us for an intensive 6-hour workshop hosted by M&S Decisions that presents a practical guide for applying AI to your most common pharmacometrics challenges.
With increasingly tight timelines and uncompromised expectations for scientific rigor, the integration of AI into daily PMx workflows is no longer optional – it is obligatory. Our team has systematically explored, tested, and distilled the most useful AI applications for practical PMx tasks and would like to share this knowledge with our peers through this workshop. Whether you are curious, skeptical, or already working with AI, this workshop will be beneficial in creating cohesive narrative of current applicability of AI agents in MID3.
What you will learn:
- Practical skills on how to use open AI agents for PMx tasks using CURSOR as a case example.
- AI-based techniques for data mining and data extraction.
- How to develop advanced web applications for your PMx models with zero coding.
Workshop program:
| Time | Topic | Details |
| 10:00 – 12:00 | Introduction to AI and its application in PMx | · Diversity of AI tools and key principles of underlying mathematical methods.
· What to choose and how to use: classification of AI tools based on their strengths and limitations; case examples: data mining and data extraction, code and text generation and quality check, model building and evaluation, UI/UX. |
| 12:00 – 13:00 | Coffee Break and Networking | |
| 13:00 – 15:40 | Hands-on | 1. Initiating work with CURSOR agent.
2. Working with the code of complex pharmacometrics models: · quality check and code lintering · between-software translation · steady-state derivation · automatic reporting 3. Effective communication and application: · automatic reporting · simulations · GUI zero-coding |
| 15:40 – 16:00 | Concluding remarks and Q&A | |
Mentors:
Anna Mishina, Dr. Veronika Voronova, Dr. Leonid Stolbov, Dr. Victor Sokolov
Fees (excl. VAT):
– Industry: €400 (€200 online)
– Academics: €200 (€100 online)
– Students: €100 (free online)
25 offline seats + 25 online seats
Technical requirements:
Mandatory: a laptop with the pre-installed CURSOR app (https://cursor.com/) with a free CURSOR account ready for use.
Optional: R version 4.2.3 or above with working rxode2 library (version 4.1.0 or above).
Simulation and parameter estimation with rxode2 and nlmixr2
This will be a hands-on course diving into pharmacometric nonlinear mixed-effects model development and simulation using the powerful rxode2 and nlmixr2 tools. Whether you’re new or looking to sharpen your skills, this half-day course will walk you through practical examples, tips and the rapidly growing ecosystem that has grown up around them. Don’t miss out on this great chance to connect and learn from the developers and seasoned users!
We’ll be covering a host of new features and support packages, including ggPMX, nonmem2rx, monolix2rx, babelmixr2, posologyr, nlmixr2lib, nlmixr2rpt, nlmixr2autoinit and as many more as we can reasonably fit into our tightly-packed schedule.
Our faculty will include Bill Denney, Anne Keunecke, Theodoros Papathanasiou, Giuseppe Pasculli, Justin Wilkins and Zhonghui Huang.
Tickets are available here
Clinical Pharmacology Insights for Enhanced Model Informed Drug Development
Date: Tuesday, June 2nd
Time: 14:00 – 18:00
Venue: Valamar Lacroma Hotel. Meeting Room: ELAFITI 1
Description:
This half-day workshop bridges clinical pharmacology fundamentals with advanced pharmacometrics applications, demonstrating how their integration drives efficient early phase drug development. Participants will gain practical insights into modern trial design strategies that maximize data utility and accelerate decision-making.
- Master Early Phase Fundamentals: Learn core principles of clinical pharmacology in early phase trials, focusing on strategies and regulatory perspectives (FDA, MHRA, EMA) for FIH studies. Learn practical insights from case studies.
- Recognize the Strategic Value of Integrated Early Phase Studies: Explore how clinical pharmacology and pharmacometrics synergy enables the evolution from sequential to integrated, overlapping trial designs that inform future development stages while reducing time and cost. Examine case studies demonstrating practical applications including cQTc modeling, DDI assessments, special populations, etc.
- Streamline Oncology Development with Project Optimus Through Model-Informed Approaches: Understand how model-informed integrated approaches support the FDA’s Project Optimus framework in oncology, moving from first in human dose to RP2D selection – including case studies.
Fees:
Free of Charge
Workshop: Mastering covariate modeling: Hands-on with the Full Random Effects Model (FREM) approach
Date: Tuesday, June 2nd
Time: 9.00-17.00
Venue: Valamar Lacroma Hotel, meeting room: Glass Office
Description:
This workshop provides theoretical insights and hands-on training (using R, NONMEM, and PsN) in applying the Full Random Effects Model (FREM) to integrate covariate data into your modeling process effectively for robust decision-making in pharmacometrics.
The workshop dives deep into the FREM methodology. You will gain practical experience using FREM to assess how different factors affect model predictions and ultimately drive decision-making in drug development. The session will also include hands-on exercises where participants will implement FREM in real-world case studies, reinforcing learning and building confidence in using this approach for model-based decision support.
By the end of this workshop, you will:
- Understand the fundamentals of the FREM methodology.
- Gain hands-on experience implementing FREM for model-based decision-making in various pharmacometric contexts.
- Learn to interpret and apply FREM results to improve modeling and decision-making processes.
You will be equipped with the skills and knowledge to implement FREM for assessing covariate impacts and support decision-making in pharmacometrics.
Workshop tutors: Niclas Jonsson, Pharmacometrics Scientific Lead and Joakim Nyberg, Chief Technology Officer.
Fees:
Ordinary: 600 euro excl. VAT
Early bird**: 450 euro excl. VAT
Students: 250 euro excl. VAT
** Early bird rate until April 17
PBPK & PBBM: linking biopharmaceutics to clinical performance with OSP suite
Date: Tuesday, June 2nd
Time: 9.00-17.00
Venue: Royal Hotels and Resort (5-min walk from Valamar Lacroma hotel), meeting room: Kalamota
Description:
Attend an online half-day or full-day on-site. This workshop will give you the experience you need to use and leverage the Open Systems Pharmacology (OSP) suite to link biopharmaceutics properties to clinical performance and address formulation-related questions throughout drug development, thereby increasing your capabilities to support decision-making in drug development.
The workshop will involve both the standardized, well-established whole-body PBPK model provided in PK-Sim® and the open modeling capabilities in MoBi®, together with specialized R packages.
The workshop covers aspects such as:
● The fundamentals in PK-Sim and MoBi
● Set up for oral PBBM in PK-Sim
● Analyses and integration of in vitro dissolution and permeability data leveraging R-packages and MoBi
● Predictions of clinical performance (PK) and relative bioavailability based on biopharmaceutics drug properties
● Predictions of food effects to inform study designs and support labeling
● Predictions of drug-drug interactions mediated by changes to gastric pH (e.g., Proton Pump Inhibitors)
The workshop is structured as a hybrid event. The morning session will feature a lecture and live demonstration, open to both on-site and remote participants. The afternoon session will be a hands-on workshop focused on dissolution and permeability modeling, available exclusively for those attending on-site. The hands-on component will utilize the latest version of R packages based on the PBBM framework developed by Vrenken et al.
Workshop tutors: Assoc. Prof. Erik Sjögren, PBPK & PBBM Scientific Lead and Paul Vrenken, Associate, MIDD Consultant
Onsite full day:
Ordinary: 600 euros excl. VAT
Students: 250 euros excl. VAT
Online morning session only:
Ordinary: 150 euros excl. VAT
Students: 75 euros excl. VAT
Scientific Machine Learning for Pharmacometrics with DeepPumas
Date: Monday, Jun 1 to Tuesday, Jun 2
Time: 09:00 – 17:00
Venue: Valamar Lacroma Hotel, Dubrovnik
Description:
This hands-on workshop covers the integration of domain knowledge with data-driven methods in pharmacometric modeling using DeepPumas. We’ll bridge mechanistic NLME modeling with modern scientific machine learning (SciML), including Neural ODEs, Universal Differential Equations, and DeepNLME, to discover unknown dynamics, leverage rich auxiliary data through embedding models, and build individualized models while maintaining interpretability.
You’ll learn how techniques from generative AI connect to random effects modeling, how SciML methods enable data-driven discovery of biological mechanisms, and how pre-trained embedding models extract prognostic information from complex data modalities.
The workshop shows how these seemingly disparate techniques (Neural ODEs, DeepNLME, embeddings, and generative models) relate to each other and integrate into a coherent framework for modern pharmacometric modeling.
Beyond teaching specific tools, the workshop offers perspective on the evolving landscape of pharmacometric modeling as machine learning transforms the field. It helps individual modelers upskill and strategists understand what will be important going forward.
Instructors: Niklas Korsbo and Lucas Pereira
What you will Learn:
The workshop covers material from classical NLME to DeepNLME, with a focus on practical implementation and real-world applications.
Practical Information
- Format: Intensive hands-on workshop with mixture of lectures, live coding demonstrations, and guided exercises
- Prerequisites: Familiarity with population modeling concepts; basic programming experience helpful but not required
- Software: All materials use Pumas/DeepPumas (Julia-based); no prior Julia experience needed
- Materials: All code, data, and documentation provided
Maximum participation of 20 attendees
Fees:
- $500 for Industry
- $100 for Academia
- Bring Your Team, Save More! Groups of 3+ qualify for a group discount.
For the Agenda and more details click here: PUMAS AI Full Agenda and Details
SimulationsPlus: MonolixSuite Workshops at PAGE 2026
Organized and delivered by: Simulations Plus, Inc.
Workshop 1:
MonolixSuite Modeling Lab: Practical Solutions for Advanced PKPD Challenges
Date & Time: June 1-2, 2026 (Monday Afternoon 1 – 5 PM and Tuesday Morning 8 AM – 12 PM)
Venue: ROYAL HOTELS & RESORT | Kardinala Stepinca 31 | 20 000 Dubrovnik | Croatia
Complex model development requires more than following a standard workflow; it requires understanding and interpretation of estimation algorithms and diagnostics. This modeling Lab moves beyond reviewing software features and focuses on practical problem solving to help you make good modeling decisions.
During technical lectures and guided hands-on sessions, you will explore diagnostic tools using different settings, gain practical insight into estimation algorithms behaviour, and work through examples of complex model building. Part of the session includes interactive troubleshooting based on real issues encountered in Monolix support, illustrating how to approach problems from both a modeling and technical perspective.
To make the experience as relevant as possible, participants are invited to pre-submit specific questions, datasets or models (details provided after registration), with selected cases discussed live during the workshop.
New to MonolixSuite? No problem. To support participants with different backgrounds, registration includes free access to our online beginner training. These self-paced resources help you get the most out of the live, instructor-led coaching.
Fees:
€800 – Industry
€400 – Students (Full day workshop — includes access to the half day AI Lab at no additional cost)
Contact : support@simulations-plus.com
Workshop 2
MonolixSuite Workflow Lab: From Automated Analysis to Submission-Ready Deliverables
Date & Time: June 1-2, 2026 (Monday Afternoon 1 – 5 PM and Tuesday Morning 8 AM – 12 PM)
Venue: ROYAL HOTELS & RESORT | Kardinala Stepinca 31 |20 000 Dubrovnik | Croatia
The transition from manual, one-off analyses to standardized, automated pipelines is changing how modellers handle frequent data updates, reruns, tight timelines, and review expectations. This workflow Lab helps to make that transition by building end-to-end workflows that are reproducible, traceable, and ready for efficient internal and regulatory review.
Through technical lectures and guided hands-on exercises, you will learn to automate data formatting and plots customization via presets, run Monolix automatically with lixoftConnectors, standardize outputs, and generate reports with Quarto. The course also covers practical quality and submission-oriented practices, including software installation documentation/validation, version control, and generating standardized output and plot packages for submissions. By the end of the workshop, you will have a structured workflow example that supports reproducibility, traceability, and submission preparation and can be adapted to your own projects.
New to MonolixSuite? No problem. To support participants with different backgrounds, registration includes free access to our online beginner training. These self-paced resources help you get the most out of the course.
Fees:
€800 – Industry
€400 – Students (Full day workshop — includes access to the half day AI Lab at no additional cost)
Contact: support@simulations-plus.com
Workshop 3:
MonolixSuite AI Lab: From Concepts to Agents—Practical AI Use Cases for Modelers
Date & Time: June 2, 2026 (Tuesday Afternoon 1 – 5 PM)
Venue: ROYAL HOTELS & RESORT | Kardinala Stepinca 31 | 20 000 Dubrovnik | Croatia
Large Language Models (LLM) are widely discussed across the industry, but their practical and safe application within a regulated scientific environment remains little understood. In pharmacometrics, there is a gap between a generic AI response and outputs that are reproducible, reviewable and appropriate for scientific decision making. This AI Lab addresses that gap with a practical, hands-on introduction to MonolixSuite specialized AI assistants.
Working with early access beta tools in MonolixSuite, you will use guided examples to explore how AI can support tasks such as drafting model elements, generating code, and supporting workflows. The session includes an introduction to the Model Context Protocol (MCP) to connect AI assistants with a modeling environment. By including realistic applications and acknowledging current limitations, the AI Lab will help you develop a clear view on what AI can support today, and how to use these tools safely and effectively in your own workflows.
New to MonolixSuite? No problem. To support participants with different backgrounds, registration includes free access to our online beginner training. These self-paced resources help you get the most out of the course.
Fees:
€400 – Industry
€200 – Students (Free for participants registered for any of the full day workshops)
Contact: support@simulations-plus.com
Essential Communication Skills for Pharmacometricians
Date: Tuesday, June 2nd
Time: 08:00 – 12:00
Venue: Valamar Argosy Hotel
Description:
Pharmacometrics is used to support rational and data-driven decision making, but often the impact of our modelling is lost, not because our technical work isn’t solid, but because of our inability to convey the relevant information to decision makers. This interactive half day workshop will cover critical soft skills for all pharmacometricians to ensure that our important work is understood, appreciated, and utilized!
Workshop instructors:
Stacey Tannenbaum, PhD, FISoP, SJTPharm LLC, USA
Janice Goh, PhD, A*STAR Bioinformatics Institute, Singapore
Fees:
300 EUR, 150 EUR for trainees
includes a light breakfast and buffet lunch following the workshop
8-40 participants
www.clinicalpharmacy.me 
Managing Complex Drug-Drug-Gene Interaction in Real World Patients with PBPK Modeling – From mechanistic model to bedside decision
Date: Tuesday, June 2nd 2026
Time: 09:30 – 16:30
Venue: Valamar President Hotel, Meeting room: Olipa 1
Description:
Why this workshop
A 68-year-old kidney transplant patient is on tacrolimus. He develops invasive aspergillosis and needs voriconazole. He also takes omeprazole for reflux. He is a CYP3A5 non-expresser and a CYP2C19 intermediate metabolizer. Three drugs, two enzymes, two genetic variants, and a drug with a narrow therapeutic window. Which dose do you give?
Cases like this are not edge cases. They are on Tuesday morning in a transplant ward. There are no drug labels for this combination, no guidelines to fall back on, single DDI calculators ignore the genetics, and clinical intuition runs out of road fast. PBPK modeling can answer these questions quantitatively, and this workshop shows you how, end to end, a real patient.
What you will do
Working in PK-Sim®, you will build and simulate combined drug-drug-gene interaction (DDGI) scenarios from literature derived parameters, evaluate different parameterization strategies, and derive model-based dose recommendations for individual patients. We then show how the same mechanistic models feed into a clinical decision support system (DSS) developed in the SafePolyMed project (safepolymed.eu), so you see the full path from model file to clinical recommendation.
Topics covered
- Implementing and simulating DDIs, DGIs, and combined DDGI scenarios in PK-Sim®
- Comparing parameterization and modeling strategies for complex interactions
- Applying PBPK models to multimorbid patients with comedications and genetic variability
- Derive model-based dose adaptations for individual cases
- Translating PBPK models into clinical practice through decision support systems
What you take home
Workshop slides, the patient case models, and access to the online DSS so you can reproduce every step at your own institution.
Who should attend
Anyone who cares about getting the dose right when drugs, comedications, and genetics collide. That includes pharmacometricians, modelers, clinical pharmacologists, clinical pharmacists, and physicians, but really, if the topic interests you, you belong in the room. To get the most out of the hands-on sessions, you should be comfortable navigating PK-Sim® on your own.
What to bring
Please bring your own laptop with PK-Sim® installed (free download at open-systems-pharmacology.org). If you are new to PK-Sim®, our Moodle courses (courses.clinicalpharmacy.me) will get you ready in time. Registered participants receive Moodle access automatically.
Workshop Team
Workshop Leads: Dr. Fatima Marok and Prof. Dr. Thorsten Lehr
Instructors: Charlotte Dette, Dr. Simeon Rüdesheim, Dr. Dominik Selzer, Veronika Alberg
Clinical Pharmacy, Saarland University, Germany
Practical details
- Participants: 5 to 30, seats are limited and demand is high
- Cost: Free of charge, made possible through the SafePolyMed project
- Catering: Coffee, other drinks, and snacks provided. Lunch on your own
- Confirmation: Registered participants will be asked to confirm attendance one week before the workshop. Unconfirmed seats will be released to the waitlist
Registration
Register for the workshop here: Workshop registration link