abstracts-archive - PAGE Meeting (Population Approach Group Europe)

Abstracts found: 6935

Animal Health Modeling & Simulation Society (AHM&S): A new society promoting model-based approaches for a better integration and understanding of quantitative pharmacology in Veterinary Sciences

Abstract number: 2849

Poster: Other Modelling Applications

Martin Fink (1), Jonathan P. Mochel (1,2), Johan Gabrielsson (3), Wendy Collard (4), RonetteGehring (5), Celine Laffont-Rousset (6), Yahong Liu (7), Tomas Martin-Jimenez (8), LudovicPelligand (9), Jean-Louis Steimer (1), Pierre-Louis Toutain (6), Ted Whittem (10), and Jim Riviere (5)

2013 - Glasgow - Scotland

Improving priors for human mAb linear PK parameters by using half-lives from pre-clinical studies

Abstract number: 5736

Poster: Oral: Methodology - New Modelling Approaches

Martin Fink (1), Philip J Lowe (1), Vittal Shivva (2)

2016 - Lisboa - Portugal

Informative study designs: The value of within-subject dose-escalation in the ‘Espresso design’

Abstract number: 8463

Poster: Methodology - Study Design

Martin Fink (1), Mark N. Milton (2), and Philip J. Lowe (1)

2018 - Montreux - Switzerland

Development of a mechanistic PK/PD model to describe drug resistance using data from an in vitro dynamic PK/PD model.

Abstract number: 3514

Poster: Drug/Disease modeling - Infection

Woloch C (1,2,3), Ba B (4), Benay S (1), Marouani H (1), Iliadis A (1)

2015 - Hersonissos, Crete - Greece

Population Pharmacokinetics of Mefloquine and its Major Metabolite in Healthy Volunteers.

Abstract number: 2217

Poster: Other drugs and diseases

C. Woloch (1), H. Marouani (1), D. Parzy (2), Iliadis A (1)

2011 - Athens - Greece

Population Pharmacokinetics of 5FU and its Major Metabolite 5-FDHU in Colorectal Cancer Patients

Abstract number: 1890

Poster: Applications- Oncology

C. Woloch (1), J. Ciccolini (1), A. Di Paolo(2), A. Iliadis (1)

2010 - Berlin - Germany

Physiologically-Based Pharmacokinetic (PBPK) Modelling of Bisoprolol in Adults and Children and External Model Validation in a Paediatric Clinical Trial

Abstract number: 1780

Poster: Applications- CVS

A.-K. Frobel, S. Ramusovic, S. Läer

2010 - Berlin - Germany

Impact of non-adherence to antiretroviral therapy in HIV-infected children

Abstract number: 2092

Poster: Paediatrics

C. Piana (1), M. Danhof (1), O.E. Della Pasqua (1,2)

2011 - Athens - Greece

Non-adherence to antiretroviral combination therapy in HIV-infected children

Abstract number: 2524

Poster: Paediatrics

C. Piana (1), M. Danhof (1), O.E. Della Pasqua (1,2)

2012 - Venice - Italy

Pharmacokinetics of paclitaxel and its metabolites using a mechanism-based model

Abstract number: 1912

Poster: Applications- Oncology

Martin Fransson(1), Henrik Gréen(2), Jan-Eric Litton(1), Lena E. Friberg(3)

2010 - Berlin - Germany

Pharmacokinetic/pharmacodynamic (PK/PD) Analysis of Teriflunomide in Patients with Relapsing Forms of Multiple Sclerosis (RMS)

Abstract number: 2562

Poster: Covariate/Variability Model Building

Nassim Djebli (1), Clémence Rauch (1), Sandrine Turpault (2) and David Fabre (1)

2012 - Venice - Italy

Coping with Time Scales in Disease Systems Analysis: Application to Bone Remodelling

Abstract number: 1998

Poster: Oral: Methodology - New Modelling Approaches

Stephan Schmidt (1), Teun M. Post (2), Lambertus A. Peletier (3), Massoud A. Boroujerdi (1), Oscar E. Della Pasqua (1,4), Meindert Danhof (1)

2011 - Athens - Greece

Implication of differences in model parameterisation in osteoporosis

Abstract number: 1800

Poster: Methodology - Model Evaluation

Stephan Schmidt (1), Teun Post (2), Massoud Boroujerdi (1), Lambertus A. Peletier (3), Meindert Danhof (1), Oscar Della Pasqua (1, 4)

2010 - Berlin - Germany

Mechanistic Prediction of Acetaminophen Metabolism and Pharmacokinetics in Children using a Physiologically-Based Pharmacokinetic (PBPK) Modeling Approach

Abstract number: 2945

Poster: Absorption and Physiology-Based PK

Xi-Ling Jiang (1, 2), Ping Zhao (2), Lawrence J. Lesko (1), Stephan Schmidt (1)

2013 - Glasgow - Scotland

Evaluation of changes in oral drug absorption in preterm neonates for BCS class I and II compounds

Abstract number: 3046

Poster: Drug/Disease modeling - Paediatrics

Amit A. Somani(1), Kirstin Thelen(2), Songmao Zheng (1), Mirjam N. Trame (1), Katrin Coboeken(2), Michaela Meyer(2), Katrin Schnizler(2), Ibrahim Ince(2), Stefan Willmann(2), Stephan Schmidt+

2014 - Alicante - Spain

Optimal dosing of lidocaine for seizure control in preterm and term neonates using population pharmacokinetic modelling and simulation

Abstract number: 1698

Poster: Applications- CNS

Marcel PH van den Broek (1), Alwin DR Huitema (2), Floris Groenendaal (3), Antoine CG Egberts (1,4), Carin MA Rademaker (1), Linda S de Vries (3)

2010 - Berlin - Germany

Population semi-mechanistic modelling of tumour response elicited by Immune-stimulatory based therapeutics in mice

Abstract number: 2719

Poster: Oncology

Zinnia P Parra-Guillen (1), Pedro Berraondo (2), Emmanuel Grenier (3), Benjamin Ribba (4) and Iñaki F Troconiz (1)

2013 - Glasgow - Scotland

Target Mediated Drug Disposition Model to Describe the Expression and Kinetics of IL12 And IFNγ in Gene Therapy

Abstract number: 2119

Poster: Other topics - Applications

Zinnia Parra Guillén(1), Rubén Hernández-Alcoceba(2), Gloria González-Aseguinolaza(2), Pedro Berraondo(2), Iñaki F. Trocóniz(1)

2011 - Athens - Greece

Nonlinear Pharmacokinetic Model For Interleukin-12 Gene Therapy

Abstract number: 1899

Poster: Methodology- PBPK

Parra-Guillen ZP(1), Hernandez-Alcoceba R(2), Gonzalez-Aseguinolaza G(2), Berraondo P(2), Troconiz IF(1)

2010 - Berlin - Germany

Development of a whole body physiologically-based pharmacokinetic (PBPK) model for inhaled salmeterol to predict interactions with CYP3A4 inhibitors

Abstract number: 8597

Poster: Drug/Disease Modelling - Absorption & PBPK

Tobias Kanacher (1) Ashish Sharma (2) José-David Gómez-Mantilla (2)

2018 - Montreux - Switzerland

A model-based approach to extrapolate drug-drug interactions from rats to humans

Abstract number: 7384

Poster: Drug/Disease Modelling - Other Topics

C. Piana (1), P. Mazzei (1), G. Smania (1), P. Magni (2), A. Lecci (1), A. Capriati (1), A. Pellacani (1)

2017 - Budapest - Hungary

Development of a translational pharmacokinetic-biomarker-efficacy model in mouse to support dose recommendation in human

Abstract number: 9127

Poster: Drug/Disease Modelling - Oncology

Tagliavini A. (1) , Borella E. (1), Piana C. (1), Sanna M.D. (1), Mazzei P. (1), Troconiz I.F. (2), Windak R.(3), Brzózka K. (3), Baldini S. (1), Goso C. (1), Merlino G. (1), Tomirotti A. (1), Tagliacozzi D. (1), Capriati A. (1), Pellacani A. (1)

2019 - Stockholm - Sweden

Optimal sampling and model-based dosing algorithm for busulfan in bone marrow transplantation patients.

Abstract number: 2776

Poster: Study Design

C. Piana (1), F. A. Castro (2), V.L. Lanchote (2), B.P. Simões (3); O.E. Della Pasqua (1,4)

2013 - Glasgow - Scotland

A novel model-based methodology for the evaluation of abuse potential

Abstract number: 5788

Poster: Drug/Disease modeling - Other topics

Chiara Piana (1), Shaonan Wang (1), Roberta Bursi (1)

2016 - Lisboa - Portugal

The Influence Of Covariate Distribution On The Prediction And Extrapolation Of Pharmacokinetic Data In Children.

Abstract number: 1898

Poster: Methodology - Model Evaluation

C. Piana(1), M. Danhof(1), O.E. Della Pasqua(1,2)

2010 - Berlin - Germany

Once Daily Pharmacokinetics Of Lamivudine In HIV-Infected Children

Abstract number: 1896

Poster: Applications- Other topics

C. Piana(1), K. Adkinson(2), M. Danhof(1), , O.E. Della Pasqua(1,3)

2010 - Berlin - Germany

Mechanistic modeling of a novel oncolytic virus, V937, to describe viral kinetic and dynamic processes following intratumoral and intravenous administration

Abstract number: 9621

Poster: Drug/Disease Modelling - Oncology

Zinnia P Parra-Guillen1,2, Tomoko Freshwater3, Youfang Cao4, Kapil Mayawala3, Sara Zalba Oteiza1,2, Maria J Garrido1,2, Dinesh de Alwis3, Iñaki F. Troconiz1,2

2021 - Online - In the cloud

A physiologically-based pharmacokinetic/pharmacodynamic framework to support clinical development of V937, a novel oncolytic virus

Abstract number: 10070

Poster: Oral: Drug/Disease Modelling - Oncology

Zinnia P Parra-Guillen(1,2), Iñaki F Trocóniz(1,2), Sara Zalba(1,2), María J Garrido(1,2), Kapil Mayawala(3), Dinesh de Alwis(3), Tomoko Freshwater(3)

2022 - Ljubljana - Slovenia

Optimal study design for pharmacokinetic modeling of teicoplanin in critically ill children, including those undergoing Continuous Renal Replacement Therapy

Abstract number: 10974

Poster: Drug/Disease Modelling - Paediatrics

Gastón García-Orueta (1); Natalia Riva (1,2); Iñaki F Trocóniz (1,2,3); Zinnia P Parra-Guillen (1,2)

2024 - Rome - Italy

Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases

Abstract number: 8909

Poster: Oral: Drug/Disease Modelling

Zinnia P Parra-Guillén (1,2), Diego Vera-Yunca (1,2), Lei Jiang (3), Marjie Hard (3), Lin T. Guey (3), Iñaki F. Troconiz (1,2)

2019 - Stockholm - Sweden

Exploring the impact of study design on unperturbed tumour growth inhibition modelling

Abstract number: 7094

Poster: Methodology - Model Evaluation

Zinnia P Parra-Guillen (1), Victor Mangas-SanJuan (1), Iñaki F Troconiz (1), Gary Mo (2), Celine Pitou (2), Philip W Iversen (3), Johan E Wallin (2)

2017 - Budapest - Hungary

A quantitative modelling framework to inform dose selection of Xentuzumab, a dual insulin-like growth factor-I/II neutralizing antibody in cancer patients

Abstract number: 8458

Poster: Oral: Drug/Disease Modelling

Zinnia P Parra-Guillen (1,2), Alvaro Janda (1,2,#), Ulrike Schmid (3), Matthias Freiwald (3), Iñaki F. Troconiz (1,2)

2018 - Montreux - Switzerland

Pharmacokinetic analysis of midazolam and caffeine as probe drugs for cytochrome phenotyping in erlotinib treatment

Abstract number: 6005

Poster: Drug/Disease modeling - Oncology

Zinnia P. Parra-Guillen (1), Markus Joerger (2), Benjamin Berger (3), Manuel Haschke (3), Charlotte Kloft (1)

2016 - Lisboa - Portugal

Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer

Abstract number: 3212

Poster: Drug/Disease modeling - Oncology

Zinnia Parra-Guillen (1) (2), Josep María Cendrós Carreras (3), Concepción Peraire (3), Rosendo Obach (4), Joan Prunynosa (3), Eric Chetaille (5) and Iñaki F Troconiz (1)

2014 - Alicante - Spain

Tumour Growth Modelling In Immunotherapy

Abstract number: 2581

Poster: Oncology

Zinnia Parra Guillén(1), Pedro Berraondo(2), Benjamin Ribba(3) Iñaki F. Trocóniz(1)

2012 - Venice - Italy

A Pharmacokinetic Study of Ranitidine in a Paediatric Population

Abstract number: 1886

Poster: Methodology - Other topics

P. Westwood, P. Collier, S. Yakkundi

2010 - Berlin - Germany

Dose-Response-Dropout Analysis for Somnolence in Pregabalin-treated Patients with Generalized Anxiety Disorder

Abstract number: 1703

Poster: Oral Presentation: Lewis Sheiner Student Session

Lay Ahyoung Lim (1), Raymond Miller (2), Kyungsoo Park (1)

2010 - Berlin - Germany

Development of a longitudinal model for characterizing adverse events of psychiatric drugs in routine clinical care

Abstract number: 2177

Poster: Other topics - Applications

Lay Ahyoung Lim (1), Eun Lee (2), Kyungsoo Park (1)

2011 - Athens - Greece

Model-based evaluation of DAS28 as a potential surrogate for ACR20 to establish the dose-response relationship for disease modifying anti-rheumatic drugs. A case study using tasocitinib (CP-690,550), an oral JAK inhibitor.

Abstract number: 1704

Poster: Applications- Other topics

Yoon Jung Lee (1), Sriram Krishnaswami (2), Lutz Harnisch (3), Jonathan French (2), Kyungsoo Park (1)

2010 - Berlin - Germany

Modeling Sunitinib and Biomarker Response as potential Predictors of Time to Progression in Patients with Metastatic Colorectal Cancer

Abstract number: 2354

Poster: Oncology

Friederike Kanefendt (1), Andreas Lindauer (1), Martina Kinzig (2), Max Scheulen (3), Dirk Strumberg (4), Richard Fischer (5), Fritz Sörgel (2), Klaus Mross (6), Ulrich Jaehde(1)

2012 - Venice - Italy

A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated P.falciparum malaria

Abstract number: 2583

Poster: Infection

Richard Höglund (1), Ishag Adam (2), Warunee Hanpithakpong (3), Michael Ashton (1), Nicholas Day (3,4), Nicholas White (3,4), Niklas Lindegardh (3,4), Francois Nosten (3,4,5), Joel Tarning (3,4)

2012 - Venice - Italy

Artemether-lumefantrine coadministration with antiretrovirals; population pharmacokinetics and dosing implications

Abstract number: 3498

Poster: Drug/Disease modeling - Infection

Richard M. Hoglund (1,2), Pauline Byakika-Kibwika (3,4), Mohammed Lamorde (4), Concepta Merry (4), Michael Ashton (5), Warunee Hanpithakpong (1), Nicholas P. J. Day (1,2), Nicholas J. White (1,2), Angela Äbelö (5), Joel Tarning (1,2)

2015 - Hersonissos, Crete - Greece

Pharmacokinetic-pharmacodynamic modelling of artesunate in patients with drug resistant and sensitive malaria

Abstract number: 7222

Poster: Oral: Drug/Disease Modelling

Richard M. Hoglund (1,2), Elizabeth Ashley (1,2), Arjen Dondorp (1,2), Markus Winterberg (1,2), Nicholas P.J. Day (1,2), Nicholas J. White (1,2), Joel Tarning (1,2)

2017 - Budapest - Hungary

Multidrug-resistant genotypes are associated with therapeutic failure of antimalarial therapy in Cambodia; a pharmacometric approach

Abstract number: 9035

Poster: Drug/Disease Modelling - Infection

Richard M. Hoglund (1,2), Chanaki Amaratunga (3), Sokunthea Sreng (4), Pharath Lim (3), Seila Suon (4), Nicholas P. J. Day (1,2), Nicholas J. White (1,2), Rick Fairhurst (3), Joel Tarning (1,2)

2019 - Stockholm - Sweden

Pharmacokinetics and pharmacodynamics of ivermectin and its metabolites

Abstract number: 9850

Poster: Drug/Disease Modelling - Infection

Richard M. Hoglund (1,2), Borimas Hanboonkunupakarn (1,5), Kevin C. Kobylinski (3), Phornpimon Tipthara Wong (1), Benjamas Sriburin (1), Podjanee Jittamala (4), Nicholas P.J. Day (1,2), Nicholas J. White (1,2), Joel Tarning (1,2)

2021 - Online - In the cloud

An Application of Optimal Design to Dose Selection and Sample Size Determination with a Negative-Binomial Exposure-Response Model for a Phase IIb Study

Abstract number: 2060

Poster: Study Design

Gordon Graham

2011 - Athens - Greece

Continuous time Markov modelling of relapse sojourns for relapse-remitting multiple sclerosis patients

Abstract number: 1849

Poster: Applications- CNS

Gordon Graham, Francois, Mercier, Mick Looby Amy Racine

2010 - Berlin - Germany

A joint PK/PD-PD model of levodopa in patients with Parkinson’s disease: Motor effect and Movement disorder

Abstract number: 2366

Poster: Other Drug/Disease Modelling

N. Simon (1), A. Boulamery (1), JP. Azulay (2), R. Viallet (3), S. Arguillère (3), B. Bruguerolle (1)

2012 - Venice - Italy

Population Pharmacokinetics of Amikacin in Korean Clinical Population

Abstract number: 1832

Poster: Applications- Anti-infectives

Seong Bok Jang(1), Min Soo Park(2), Young Goo Song(3), Kyungsoo Park(1)

2010 - Berlin - Germany

Population pharmacokinetic analysis of ciprofloxacin in intensive care unit adult patients

Abstract number: 1888

Poster: Applications- Anti-infectives

Dalia Khachman (1,2), Jean-Marie Conil (3,4), Bernard Georges (3,4), Sylvie Saivin (2,4), Georges Houin (2) and Celine M. Laffont (1)

2010 - Berlin - Germany