Thursday 16 October, 2025
Objectives: The Unified Parkinson’s Disease Rating Scale (UPDRS), a multi-item symptom evaluation tool that included three sub scales, is the…
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Model-based analysis of patient-derived organoids for evaluating anticancer drugs
Thursday 16 October, 2025
Introduction: Cancer organoids are a 3D in vitro cancer model that faithfully mimic the characteristics of human tumors from which…
Read moreFacing the limits of the genetic algorithms for covariate selection
Thursday 16 October, 2025
Objectives: Covariate identification is an important step in the development of a pharmacokinetic/pharmacodynamic (PK/PD) population model [1]. Among the different…
Read moreTranslational modeling of tumor response to treatment: bridging preclinical to clinical studies
Thursday 16 October, 2025
Introduction Preclinical studies play an essential role in cancer research [1]. Patient-derived xenograft (PDX) models that implant patient tumor tissue…
Read moreModel-based assessment of early bactericidal activity of rifampicin in combination with meropenem plus amoxicillin/clavulanate among adults with rifampicin-resistant pulmonary tuberculosis
Thursday 16 October, 2025
Introduction/Objectives: Meropenem and rifampicin have been reported to have synergistic activity in vitro[1], indicating that co-administration of meropenem could decrease…
Read moreNumerical validation of Tucuxi, a promising new Bayesian adaptation tool
Thursday 16 October, 2025
Objectives: Therapeutic Drug Monitoring (TDM) is increasingly used in clinical practice to adjust dosage regimens based on specific patient characteristics…
Read moreDosing optimization of amoxicillin in children treated for Lyme disease
Thursday 16 October, 2025
Context and objectives: Amoxicillin is a beta-lactam antibiotic prescribed to children to treat erythema migrans (EM), an early-localized manifestation of…
Read morePopulation pharmacokinetic study of lacosamide in children and adults with epilepsy
Thursday 16 October, 2025
Objectives: Lacosamide is an antiepileptic drug prescribed intravenously or orally for the treatment of partial seizures with or without secondary…
Read moreJoint modeling of longitudinal and time-to-event data for earlier estimation of the primary endpoint in oncology clinical trials: A retrospective analysis of the ICARIA-MM clinical trial
Thursday 16 October, 2025
Introduction: Earlier assessment of clinical trial outcomes would allow earlier decision making, especially for trials of long duration, where models developed in…
Read moreContribution of modelling jointly progression-free survival and biomarker longitudinal data for therapeutic evaluation in oncology
Thursday 16 October, 2025
Objectives: Joint modeling has been increasingly used for therapeutic evaluation in oncology, as it allows the simultaneous fit of longitudinal…
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