Thursday 16 October, 2025
CONTEXT: During drug development in oncology, a substantial amount of data is acquired to determine the safety and efficacy of…
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Innovative Machine Learning Based Algorithm to Differentiate Between Diabetes Insipidus and Primary Polydipsia in Clinical Practice
Thursday 16 October, 2025
Objectives: Differentiation between central Diabetes Insipidus (cDI) and Primary Polydipsia (PP) remains challenging in clinical practice. Although the hypertonic saline…
Read moreMathematical Modeling Of Gut Microbiota Diversity Under The Effects of Beta-lactam Antibiotics
Thursday 16 October, 2025
Introduction/Objectives Antibiotics treatments shift the composition of the gut microbiota according to their spectrum of activity, posology and intestinal excretion…
Read moreImplementation of neural ordinary differential equations in the pharmacometric software packages Monolix, NONMEM, and nlmixr
Thursday 16 October, 2025
Objectives: Neural ordinary differential equations (NODEs) are a machine learning approach to model dynamic data [1]. Compared to commonly applied…
Read moreItem Response Theory Analysis of the Scale for the Assessment and Rating of Ataxia in Autosomal Recessive Cerebellar Ataxias
Thursday 16 October, 2025
Background and objectives: Autosomal Recessive Cerebellar Ataxias (ARCAs) is a heterogenous group of rare and ultra-rare neurodegenerative genetic diseases that…
Read moreIntegrated modeling of digital-motor outcomes and clinical outcome assessments using IRT: a framework for developing better outcomes for clinical trials in rare neurological diseases
Thursday 16 October, 2025
Background: Effective trial planning for rare neurological diseases is often hindered by the lack of robust and sensitive endpoints. This…
Read moreFeedforward neural network as a surrogate for the reinforcement learning action-value function in a model-informed precision dosing oncology application
Thursday 16 October, 2025
Objective: Model-informed precision dosing (MIPD) leverages prior knowledge and biomarker data for individualized drug dosing. Such dose adjustments are particularly…
Read morePopulation pharmacokinetics of the antitubercular drug TBAJ587 and its two main metabolites
Thursday 16 October, 2025
Introduction: Diarylquinolines (DARQs) have become an essential part of regimens against Mycobacterium tuberculosis (TB)1. TBAJ587 is a next-generation DARQ being…
Read moreSemi-mechanistic model of the Haemodynamic effects of propofol and remifentanil administered in combination to patients undergoing general anaesthesia
Thursday 16 October, 2025
Introduction and Objectives. Propofol, a GABA-A receptor agonist hypnotic, and remifentanil, a short-acting opioid analgesic, are the most commonly used…
Read moreSemi-mechanistic model of pulmonary ventilation changes during propofol and remifentanil infusion as measured by minute-volume and transcutaneous pCO2.
Thursday 16 October, 2025
Introduction and Objectives: Pulmonary ventilation is significantly affected during sedation, often leading to respiratory depression and the subsequent hypoxia. Changes…
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