Thursday 16 October, 2025
Objectives: The thymus is a primary lymphoid organ whereby thymocytes differentiate into functional T cells through a process of thymopoiesis….
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Impact of sampling procedure on individual pharmacokinetic parameter estimation methods
Thursday 16 October, 2025
Objectives: Therapeutic drug monitoring represents one of the main applications of pharmacometrics in the clinical setting. Bayesian approaches are routinely…
Read moreTowards PBPK model development for oral absorption in PhysPK
Thursday 16 October, 2025
Objectives: Oral drug absorption is a complex process dependent on the interplay between processes depending on both compound and dynamic…
Read moreTitle: Development of a Compartmental Advanced Physiologically based Dissolution, Absorption and Transit (CA-PhysDAT) model in PhysPK
Thursday 16 October, 2025
Introduction: Oral drug absorption is a complex process depending on the interplay between both compound characteristics and physiological and dynamic properties…
Read moreNeural ODE structures based on pharmacokinetic principles
Thursday 16 October, 2025
Objectives: Neural ordinary differential equations (NODEs) are a machine learning (ML) approach that can fit data from dynamic systems [1],…
Read moreOpportunities of Covariate Data Imputation with Machine Learning for Pharmacometricians in R
Thursday 16 October, 2025
Introduction: A common challenge with clinical data is that there is missing covariate information [1]. Since missing data can affect…
Read moreMultivariate Exact Discrepancy : a new tool for PK/PD model evaluation
Thursday 16 October, 2025
Objectives: The criteria used to validate pharmacokinetic model can be grouped into two families. The first family comprises metrics based…
Read moreA methodology to de-shrink Empirical Bayes Estimates
Thursday 16 October, 2025
Objectives: Therapeutic drug monitoring (TDM) is used for some drugs to evaluate drugs exposures and optimize the therapeutic management of…
Read moreValue of literature review to inform development and use of biologics in juvenile idiopathic arthritis
Thursday 16 October, 2025
Introduction/Objectives: Pediatric inflammatory rheumatic diseases (PiRD) is an umbrella term for chronic inflammatory conditions affecting infants, children and adolescents. Juvenile…
Read moreCharacterizing effect of methotrexate on adalimumab PK in pediatric patients with inflammatory rheumatic disease
Thursday 16 October, 2025
Introduction/Objectives: Adalimumab is a monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), used for treatment of various inflammatory diseases,…
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