Thursday 16 October, 2025
Objectives: Model-informed precision dosing (MIPD) combines prior knowledge about drug pharmacokinetics/pharmacodynamics (PK/PD) with patient data to predict the likelihood of…
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Finch Studio: A Next Generation NONMEM Modeling Workbench
Thursday 16 October, 2025
Introduction: Finch Studio is an integrated modeling environment for pharmacometricians, clinical pharmacologists, and other team members to visualize, develop, and…
Read moreUsing preclinical data to predict human pharmacokinetics of monoclonal antibodies for first-in-human dose setting: A review of five internal case studies
Thursday 16 October, 2025
Introduction/Objectives: Therapeutic monoclonal antibodies (mAbs) have been a dominating class of new approved drugs during the last two decades. To determine…
Read moreOptimizing the Dose Escalation of a new anti-CD73 monoclonal antibody for target Inhibition: A Comprehensive Preclinical and Clinical Modelling Approach
Thursday 16 October, 2025
Objectives: S095024 (Sym024) is a monoclonal Fc-effector function attenuated antibody inhibiting CD73. CD73 is a key enzyme involved in the…
Read moreAn asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies
Thursday 16 October, 2025
Introduction: Physiology-based pharmacokinetic (PBPK) models are being increasingly utilised in pharmacometrics to understand the whole-body disposition of various drugs. They…
Read moreAn asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies
Thursday 16 October, 2025
Introduction: Physiology-based pharmacokinetic (PBPK) models are important tools for understanding the distribution and clearance of drugs in organisms. Drugs may…
Read moreIntegrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat
Thursday 16 October, 2025
Objectives: Precision Dosing is an emerging approach aiming to optimize and customize the dose and the treatment schedule at individual…
Read moreA Two-Stages Global Sensitivity Analysis in presence of correlated inputs: Application on a Tumor-in-host-growth Inhibition model based on the Dynamic Energy Budget theory
Thursday 16 October, 2025
Objectives: Global sensitivity analysis (GSA) aims to evaluate the impact of variability and/or uncertainty of the model input parameters on…
Read morePopPK-PD modelling of Carboplatin-induced myelosuppression to support therapeutic drug monitoring and dose individualization in cancer patients using Electronic Health Record Data
Thursday 16 October, 2025
Background: Carboplatin is a cytotoxic anticancer drug used in monotherapy or in combination with other chemotherapeutics and/or immunotherapies to treat…
Read morePopulation pharmacokinetic-pharmacodynamic model of subcutaneous bupivacaine in a novel extended-release microparticle formulation
Thursday 16 October, 2025
Introduction and Objectives: Improving postoperative pain management is essential to ensure better medical outcomes after surgical procedures [1]. Using local…
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