Thursday 16 October, 2025
Introduction/Objectives: Depression affects around 10% of women during the perinatal period [1]. Sertraline, a selective serotonin reuptake inhibitor, is one…
Read moreAbstracts
A pharmacokinetic-pharmacodynamic model characterizing antibiotic-induced morphological changes in Pseudomonas aeruginosa from time-lapse microscopy images
Thursday 16 October, 2025
Introduction: Pseudomonas aeruginosa are Gram-negative, rod-shaped bacilli that can cause a variety of infections, ranging from relatively non-severe urinary tract infections…
Read moreAmikacin dose optimization in the emergency department: A population pharmaco-kinetic simulation study
Thursday 16 October, 2025
Objectives: Sepsis related to Gram-negative infections is a life-threatening organ dysfunction responsible for 11 million deaths per year worldwide [1]….
Read moreModel-informed comparison of the clinical relevance of four renal function markers on meropenem target attainment in critically ill septic patients
Thursday 16 October, 2025
Introduction : Evaluation of the renal function is important in critically ill septic patients, particularly for drugs like meropenem, that…
Read morePhysiologically Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to medicines: a contribution from the ConcePTION Project
Thursday 16 October, 2025
Objectives: Breastfeeding is associated with positive health effects for mother and infant [1]. However, postpartum women often need medicines [2]….
Read morePhysiologically-Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to Sildenafil and Bosentan: a contribution from the ConcePTION Project
Thursday 16 October, 2025
Objectives: Sildenafil and bosentan are used as combined therapy for pulmonary arterial hypertension (PAH). Since pregnancy is contra-indicated for women…
Read moreThe comparison of pharmacoeconomic and pharmacometric modelling to improve cost-effectiveness assessment of sunitinib in GIST.
Thursday 16 October, 2025
Objectives: Governmental organisations are continuously making difficult decisions regarding regulatory approval, balancing drug efficacy against toxicity and costs. Pharmacoeconomic (PE)…
Read moreA Population Pharmacokinetic Model for Creatinine with and without ingestion of cooked meat
Thursday 16 October, 2025
Introduction: Estimated glomerular filtration rate (GFR) based on serum creatinine is now widely reported by clinical laboratories, and in most…
Read morePlasma and cerebrospinal fluid population pharmacokinetics of vancomycin in patients with external ventricular drain
Thursday 16 October, 2025
Introduction: Vancomycin is a standard therapy for central nervous system (CNS) infections, specifically nosocomial infections, caused by Gram-positive penicillin-resistant pathogens…
Read morePhysiologically Based Pharmacokinetic Modeling of a CYP3A4-Mediated Drug-Drug Interaction: Prediction of Victim of Induction, not Inhibition, with a Moderate Fraction Metabolized by CYP3A4
Thursday 16 October, 2025
Introduction: As part of the clinical development plan, a set of in vitro studies were undertaken to determine the drug-drug…
Read more