Thursday 16 October, 2025
Introduction: Targeted protein degradation is showing promising results for the treatment of various diseases, in particular cancer [1], mainly through…
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Coupling Quantitative Systems Pharmacology (QSP) and ML/AI: a story of pAIns and gAIns
Thursday 16 October, 2025
Introduction/Objectives: We are currently living an era where ML/AI approaches seem to be (greatly) improving more traditional methods, replacing in…
Read morePopulation analysis of the in vivo pharmacokinetic characteristics of a letrozole sustained delivery formulation in Beagle dogs
Thursday 16 October, 2025
Introduction/Objectives: Letrozole is an aromatase inhibitor that is currently marketed as oral tablets as a first line treatment for hormone-dependent…
Read moreOral amoxicillin/clavulanate in paediatric patients with severe community acquired pneumonia: a popPK analysis from the PediCAP trial
Thursday 16 October, 2025
Objectives: Amoxicillin alone or in combination with clavulanate (co-amoxiclav) is a widely prescribed antibiotic in paediatric infectious disease [1]. Its…
Read moreA Pharmacokinetic/Pharmacodynamic Model of Recombinant Batroxobin
Thursday 16 October, 2025
Objectives: Batroxobin is a thrombin-like snake venom protein purified from the venom of Bothrops atrox moojeni[2]. It cleaves only the…
Read morePhysiologically based Pharmacokinetic and Pharmacodynamic modeling of Enzalutamide and N-desmethyl enzalutamide
Thursday 16 October, 2025
Objectives: Enzalutamide (ENZ) is a second-generation androgen receptor inhibitor used in the treatment of castration-resistant prostate cancer (CRPC). The clinical…
Read moreInvestigating Alternative Daily Dose Regimens for Bedaquiline in Treatment of Multidrug-Resistant Tuberculosis using an Interactive Shiny Application
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) remains a major global health concern, especially multidrug-resistant (MDR) TB [1]. Bedaquiline (BDQ), is an effective drug for…
Read moreOcular Exposure Extrapolation Across Multiple Species Using PBPK Modeling and Simulation: Latanoprost Solution Case Study
Thursday 16 October, 2025
Objectives: Glaucoma is a disease that damages the optic nerve, leading to vision loss. In most cases, it is caused…
Read moreDisease-drug-drug interaction in drug repurposing of intravenous imatinib for COVID-19 ARDS
Thursday 16 October, 2025
Introduction: In CounterCOVID, the treatment of coronavirus disease 2019 (COVID-19) patients resulted in improved survival rates and reduced the duration…
Read morePharmacometric analysis of symptom burden during anti-cancer drug therapy by a Markov modelling approach
Thursday 16 October, 2025
Introduction: Adverse drug events (ADE) represent a great burden for patients in the treatment with antitumor drugs and can in…
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