Thursday 16 October, 2025
Introduction and objectives Understanding the natural Alzheimer`s Disease (AD) progression is important for developing disease modifying therapies [1]. Limited knowledge…
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Translational pharmacology and dose rationale for imatinib and doramapimod as a host-directed therapy for the treatment of pulmonary tuberculosis
Thursday 16 October, 2025
Introduction: Tuberculosis (TB), the resulting disease of Mycobacterium tuberculosis (Mtb) infection, affects approximately 10 million people each year, despite drugs…
Read moreProtocol optimization for the evaluation of pharmacokinetics, biomarkers and efficacy of antitubercular drugs in a novel tuberculosis infection model in marmosets
Thursday 16 October, 2025
Objectives: The development of more efficacious drug regimens against M. tb requires predictive preclinical animal models encompassing the same pathological…
Read moreAutomatic model discovery in Quantitative Systems Biology
Thursday 16 October, 2025
Introduction/Objectives: Quantitative Systems Pharmacology (QSP) models aim at offering a detailed mechanistic understanding of the biological processes underlying health, disease…
Read morePopulation pharmacokinetic analysis for pediatric patients with inflammatory bowel disease receiving infliximab
Thursday 16 October, 2025
Objectives: Inflammatory bowel disease (IBD) represents chronic inflammatory disorders affecting the gastrointestinal tract, including Crohn’s disease (CD) and ulcerative colitis…
Read moreDevelopment of a physiological-based pharmacokinetic model for sacubitril and its metabolite
Thursday 16 October, 2025
Objectives: Sacubitril/valsartan, a novel angiotensin receptor neprilysin inhibitor, has been approved for chronic heart failure treatment to reduce the risk…
Read morePopulation pharmacokinetics of intraperitoneal irinotecan and SN-38 in patients with peritoneal metastases from colorectal origin
Thursday 16 October, 2025
Objectives: Colorectal cancer (CRC) is a prevalent malignancy, accounting for approximately 10% of all cancer diagnoses worldwide [1]. At onset,…
Read moreThe effect of pH on intratumoural docetaxel release from polymeric nanoparticle CPC634
Thursday 16 October, 2025
Objectives: Docetaxel (DTX), a widely used antimitotic agent for diverse solid cancers, demonstrates great variability in clinical responses. This variability…
Read moreThe Applied Pharmacometrics Training Program – Year 3 Sustainability
Thursday 16 October, 2025
Objectives: The number of trained pharmacometricians on the African continent remains low, often driven by limited training opportunities and the…
Read morePharmacometric modelling to describe pharmacokinetics and exposure-response of ivermectin in adolescent patients infected with Trichuris trichiura
Thursday 16 October, 2025
Introduction: Soil-transmitted helminth infections are a major public health challenge in many tropical and subtropical low-income regions. Monotherapy with albendazole…
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