Thursday 16 October, 2025
Introduction: Targeted protein degraders (TPDs) are attracting considerable interest with the promise to address disease-related proteins not druggable with inhibitors due…
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Systemic and ocular physiologically based pharmacokinetic models for protein therapeutics in rabbits
Thursday 16 October, 2025
Objectives: Rabbits play a pivotal role as a highly valued small animal model, particularly in the field of ocular therapeutics, where…
Read morePharmacodynamic Drug-Drug Interaction Between Oxaliplatin and HDAC Inhibitors in Colorectal Cancer Cell Lines
Thursday 16 October, 2025
Objectives: Histone deacetylases (HDACs) are enzymes that regulate gene expression and that have been proposed as regulators for various signaling…
Read moreDevelopment of a PBPK model to predict monoclonal antibody pharmacokinetics and bioavailability following subcutaneous administration
Thursday 16 October, 2025
Introduction: Monoclonal antibodies (mAbs) are currently established components of oncology and immunology therapies, typically administered intravenously over extended treatment periods of…
Read moreA translational toolkit to predict clinical Phase IIb/III outcomes from preclinical mouse studies
Thursday 16 October, 2025
Objectives Despite known drug regimens, tuberculosis (TB) treatment remains long and complex, highlighting the urgent need to identify shorter but…
Read moreAn Integrated PBPK-Quantitative Systems Pharmacology Model for Statins to Assess the Variability and Implications of Transporter-Mediated Distribution
Thursday 16 October, 2025
Introduction: Quantitative Systems Pharmacology (QSP) models can be used to quantitatively and mechanistically describe the underlying biological/pharmacological processes in disease….
Read morePBPK model-based extrapolation from adults to children to predict furosemide oral solution bioavailability
Thursday 16 October, 2025
Introduction Furosemide is a loop diuretic that has been used in adults and children for decades, mainly for the treatment…
Read moreA first-ever mechanistic disease model of IgG4-related disease identifies high-potential therapy targets
Thursday 16 October, 2025
Objectives: IgG4-related disease (IgG4-RD) is a rare and newly discovered chronic inflammatory disease regulated by the immune system that affects…
Read moreLeveraging Open Systems Biology Standards for Improved Reusability and Reproducibility of Pharmacological Models
Thursday 16 October, 2025
Introduction/Objectives: In systems biology, open standards for model exchange and storage have been designed to enable model transfer between computing…
Read moreR framework for reproducible and quality-controlled modeling and simulation with the Open Systems Pharmacology Software
Thursday 16 October, 2025
Objectives: Physiologically-based pharmacokinetic (PBPK) and quantitative systems pharmacology/toxicology (QSP/T) modeling are crucial tools in drug development and regulatory decision-making [1]….
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