Thursday 16 October, 2025
Introduction: Neural Ordinary Differential Equations (NODEs) [1,2] constitute a promising data-driven method for modeling dynamical systems in computational biology. Recent works…
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Bayesian PBPK modeling for acyclovir dose optimization for treating viral encephalitis
Thursday 16 October, 2025
Introduction/Objectives: Viral encephalitis is a rare but life-threatening central nervous system (CNS) infection commonly caused by herpesviruses with a mortality rate…
Read moreWB-PBPK-PD Modeling for Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs
Thursday 16 October, 2025
Objectives: N-Acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs that have revolutionized RNA interfering drug therapy due…
Read moreReliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?
Thursday 16 October, 2025
Introduction: Drug pharmacokinetic (PK) profiles observed in the blood stream are not always informative about the PK within the central…
Read moreTowards an integrated mPBPK/PD model for drug-optimization and prediction of relapse after treatment of tuberculosis in mice
Thursday 16 October, 2025
Objectives: The treatment of tuberculosis (TB), one of the most harmful infectious diseases killing millions of people worldwide [1], still…
Read moreCis-binding of bispecific antibodies: effect of additional valency and dose on the antibody-target complexes formation on the example of antibody CTX8371
Thursday 16 October, 2025
Objectives: Different binding patterns of therapeutic antibodies impact the therapy effects. Novel bispecific antibodies (BsAb) may bind different targets on…
Read moreSunburst Plots for Analyzing the Impact of Drugs on CRS
Thursday 16 October, 2025
Objectives: Cytokine release syndrome (CRS) is caused by substantial, rapid release of cytokines into the circulation from immune cells, often…
Read moreExternal Validation of a Population Pharmacokinetic Model for Morphine and its Metabolites in Children under 3 Years who Underwent Cardiothoracic Surgery
Thursday 16 October, 2025
Objectives: Morphine is widely used for postoperative pain management in children. Previously, a model was developed by Valkenburg et al….
Read moreIntegrated Population PK and PBPK Modelling Approaches of IAMA-6 Plasma Concentrations following Oral, Intraperitoneal and Intravenous Administrations in Three Different Preclinical Species for First in Human Dose Prediction
Thursday 16 October, 2025
Introduction/Objectives: IAMA-6 is a small molecule, selective inhibitor of the sodium potassium chloride cotransporter (NKCC1), showing encouraging in vitro and in vivo…
Read moreCausal considerations in Exposure-Response and Population PK covariate analysis
Thursday 16 October, 2025
Background & Objectives: Pharmacometric models often address causal questions, specifically examining the impact of changing an independent variable (X) on…
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