Thursday 16 October, 2025
Introduction: Tacrolimus (TAC) is an immunosuppressant prescribed often in combination with mycophenolic acid to patients who undergo organ transplantation. TAC exerts…
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Modelling of tumour growth with respect to the use of anti-cancer agents
Thursday 16 October, 2025
Objectives: This project aimed to compare the performance of models recently published in the literature that characterise tumour volume over…
Read moreA semi-systematic review on the maturational physiology in exclusively breastfed infants: Growth – A contribution from the ConcePTION project
Thursday 16 October, 2025
Introduction: Physiologically-based pharmacokinetic (PBPK) models are a mechanistic model to predict pharmacokinetics (PK) based on study design and medicine- and…
Read moreToward Personalized Salbutamol Therapy: Validating Virtual Patient-Derived Population Pharmacokinetic Model with Real-World Data
Thursday 16 October, 2025
Objectives: The variability in patients’ therapeutic responses underscores the importance of understanding pharmacokinetics (PK) and pharmacodynamics (PD) for effective drug…
Read morePopulation Pharmacokinetics and Safety Assessment of Rifapentine in Chinese Children to Inform Dosing Recommendations for Latent Tuberculosis Infection
Thursday 16 October, 2025
Introduction Current treatment of latent tuberculosis infection (LTBI) include combined rifapentine (RFT) and isoniazid daily treatment for one month (1HP)…
Read moreA Quantitative System Pharmacology model for the development and optimization of mRNA vaccines.
Thursday 16 October, 2025
Introduction: The necessity of reducing time and costs in the development phase of a vaccine has been an open challenge…
Read moreLeveraging in vitro data from novel drug candidates to prioritize antibody combinations in autoimmune disease using a QSP model of IBD
Thursday 16 October, 2025
Objectives: For many autoimmune indications the treatment response has reached a ceiling effect and so novel combination treatment approaches may…
Read morePBPK modelling based estimation of safe, and effective Molnupiravir doses for pediatric subpopulations against SARS-CoV-2
Thursday 16 October, 2025
Introduction: Although the end of COVID-19 pandemic has been declared, SARS-CoV-2 infection cases are still being reported worldwide [1]. During…
Read moreOrgan-specific tumor dynamics predict survival of patients with metastatic colorectal cancer
Thursday 16 October, 2025
Objectives: Several tumor growth inhibition (TGI) models have been developed to evaluate the longitudinal trajectories of tumor size and their…
Read moreUsing Bayesian Modelling to Evaluate the Effect of a Neonatal Vancomycin Loading Dose on Therapeutic Target Attainment in a Low-Middle Income Country
Thursday 16 October, 2025
Introduction: Vancomycin, a glycopeptide antibiotic, has served as a cornerstone in treating hospital-acquired Gram-positive infections for over five decades. Recommended for…
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