Thursday 16 October, 2025
Introduction: Asthma is a heterogenous disease that affects millions of people worldwide. Despite the availability of multiple treatment options, a significant…
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Integrating Random Effects in Scientific Machine Learning Models for Pharmacokinetic Modeling
Thursday 16 October, 2025
Introduction: The last few years have seen a remarkable rise in the use of machine learning (ML) in clinical pharmacology…
Read moreEvaluating the utility of dose/exposure-response modeling for dose optimization in oncology
Thursday 16 October, 2025
Introduction: Conventionally, single arm dose-expansion trials were widely used to select the therapeutic dose for oncology. Many gaps in the conventional…
Read morePopulation pharmacokinetic and pharmacodynamic analysis of granulocyte colony-stimulating factor (G-CSF) to optimize dose and timing for harvesting CD34+ cells
Thursday 16 October, 2025
Objectives: Filgrastim is a well-known granulocyte colony-stimulating factor (G-CSF), a cytokine for the maturation and mobilization of bone marrow neutrophils….
Read moreA population pharmacokinetic model of N,N-dimethyltryptamine administered through continuous intravenous infusion in healthy smokers and non-smokers
Thursday 16 October, 2025
Introduction: Psychedelic agents such as N,N-dimethyltryptamine (DMT) are currently being studied for the treatment of various mental disorders [1][2]. To…
Read moreAntidepressants transplacental transfer modeling using ex vivo perfusion of isolated human placenta cotyledon
Thursday 16 October, 2025
Introduction: Depression is common in pregnant women [1]. Perinatal depression affects around 6-12% of pregnant women at different trimesters [2-3]….
Read morePopulation pharmacokinetic modelling of whole blood and intracellular tacrolimus in adult kidney transplanted patients
Thursday 16 October, 2025
Introduction: Tacrolimus is an immunosuppressive drug used to prevent organ rejection in kidney transplanted patients. It has a narrow therapeutic…
Read moreIntegrated In Vitro/In Silico Systems Immunology Model to Quantify Drug-Induced Changes in the Immune Response after Influenza A Virus Infection – A Blueprint for the Preclinical Assessment and Clinical Translation of Infection Risks for Biologics
Thursday 16 October, 2025
Objectives: Biological modalities, such as antibody-based biologics, have revolutionized the treatment of many neoplastic and inflammatory diseases over the last years….
Read moreSevoflurane Pharmacokinetics and Pharmacodynamics in Adults During General Anaesthesia
Thursday 16 October, 2025
Background Sevoflurane vapour is inhaled for the induction and maintenance of general anaesthesia. Sevoflurane vapour concentration is measured in real-time…
Read moreDelpazolid population pharmacokinetics and pharmacodynamics in patients with pulmonary tuberculosis
Thursday 16 October, 2025
Introduction: Linezolid is currently recommended for the treatment of multidrug-resistant tuberculosis (MDR-TB) by the WHO. However, this drug is associated with…
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