Thursday 16 October, 2025
Objectives: Preterm preeclampsia occurring before 34 weeks of gestation is associated with severe morbidity and mortality. Delivery is the only…
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Population pharmacokinetics of rifabutin among co-infected children on lopinavir/ritonavir-based antiretroviral therapy
Thursday 16 October, 2025
Objectives: Treatment of tuberculosis in children with HIV is challenging due to drug-drug interactions (DDI). Rifampicin, an important component of the…
Read moreA Pharmacokinetic and Pharmacodynamic Model of Cyclosporine among Malaysian Renal Transplant Patients
Thursday 16 October, 2025
Objectives: Cyclosporine (CsA) is a calcineurin inhibitor that is still one of the main drugs of choice in renal transplant…
Read morePharmacometric Modeling of Drug Adverse Effects: An Application of Mixture Models in Schizophrenia Spectrum Disorder Patients Treated with Clozapine
Thursday 16 October, 2025
Objectives: Clozapine is the drug of choice for treatment-resistant schizophrenia [1]. However, its use is limited to only 5% of…
Read moreRDarwin: An R package for Machine Learning using pyDarwin and Certara’s pharmacometrics modeling language (PML) and NLME engine
Thursday 16 October, 2025
Introduction/Objectives: RDarwin (1) is an R package that provides a set of R functions to enable setup and execution of pyDarwin…
Read moreEvaluation of the pharmacokinetics of tideglusib in congenital and childhood myotonic dystrophy type 1 using Bayesian priors
Thursday 16 October, 2025
Introduction: GSK3β is an intracellular regulatory kinase that is dysregulated in multiple tissues in Type 1 myotonic dystrophy (DM-1), a rare…
Read moreDevelopment and evaluation of D-optimal 2×2 checkerboard designs for identification of pharmacodynamic drug interactions
Thursday 16 October, 2025
Objectives: In pharmacodynamic (PD) interaction screening elucidation of the nature of the PD interaction (synergy, antagonism, additivity) is essential. Checkerboard…
Read moreA general pharmacodynamic interaction modelling approach to assess semi-mechanistic synergy of ceftazidime/avibactam and fosfomycin in time kill experiments
Thursday 16 October, 2025
Objectives: Detailed mechanistic understanding of in vitro pharmacodynamic (PD) drug interactions as provided by semi-mechanistic pharmacokinetic pharmacodynamic (PKPD) modelling is…
Read moreCefepime Population Pharmacokinetics and Target Attainment in Critically ill Patients with Estimation of Probability of Neurotoxicity
Thursday 16 October, 2025
Introduction: Cefepime is a fourth-generation cephalosporin antibiotic with a broad antibacterial spectrum[1] and exhibits time-dependent bactericidal activity like other beta-lactams[2]….
Read morePopulation Pharmacokinetic Model of Ixodes ricinus-Contact Phase Inhibitor for patients with Spontaneous Intracerebral Haemorrhage
Thursday 16 October, 2025
Introduction: Non-traumatic intracerebral haemorrhage (ICH) accounts for about 10-15% of all stroke cases. It is responsible for about 40% of…
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