Thursday 16 October, 2025
Introduction: Cyclosporine (CyA), an immunosuppressive agent, is mandatory part of post-transplantation therapy protocols. CyA shows large interindividual and intraindividual pharmacokinetic (PK)…
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A combined modelling approach to assess the efficacy and safety of doravirine in pregnant women
Thursday 16 October, 2025
Objectives: Doravirine is a relatively new second-line drug for patients living with HIV. It is regularly used in stable HIV…
Read moreDevelopment of population pharmacokinetic models using informative priors in clinical settings
Thursday 16 October, 2025
Introduction and objectives: In the clinical setting, one of the limitations of developing population pharmacokinetic (PopPK) models is the sparseness…
Read moreIn silico clinical trial simulation shows amelioration of ischemia-reperfusion injury in ST-elevation myocardial infarction via inhibition of reactive oxygen species production
Thursday 16 October, 2025
Introduction: Simulated clinical trials were run using a disease model of cardiac ischemia-reperfusion injury (IRI). The simulation suggested that: Myocardial…
Read moreA physiologically based computational model of indocyanine green liver function tests predicts survival in hepatectomy
Thursday 16 October, 2025
Objectives: The evaluation of hepatic function and functional capacity of the liver are essential tasks in hepatology, especially in the…
Read moreCaptopril in Focus: Establishing an Open Pharmacokinetic Dataset and PBPK Modeling
Thursday 16 October, 2025
Introduction: Angiotensin-converting enzyme (ACE) inhibitors, such as captopril, are widely prescribed for the treatment of hypertension and heart failure. Captopril,…
Read morePK-DB: pharmacokinetics database for individualized and stratified computational modeling
Thursday 16 October, 2025
Objectives: A multitude of pharmacokinetics studies has been published. However, due to the lack of an open database, pharmacokinetics data,…
Read morePKPD Relationship between THC Levels and Self-Assessment of Driving Proficiency Among Cannabis Users
Thursday 16 October, 2025
Objectives: The World Drug Report 2023 by the United Nations Office on Drugs and Crime (UNODC) identifies cannabis as the…
Read moreMathematical modelling of the molecular mechanisms of interaction of tenofovir with emtricitabine against HIV
Thursday 16 October, 2025
Objectives: The two nucleoside reverse transcriptase inhibitors (NRTI) Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used in combinationfor treatment of…
Read moreIs the model predictive performance with von Willebrand factor superior to others? An external evaluation of population pharmacokinetic models for FVIII concentrate BAY 81-8973 in pediatric patients with haemophilia A
Thursday 16 October, 2025
Objectives: Pharmacokinetics-tailored dosing of factor VIII (FVIII) has become a popular solution for personalized prophylactic treatment in hemophilia A [1]….
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