Thursday 16 October, 2025
Objectives: In patients with recurrent prostate cancer, the addition of docetaxel to androgen-deprivation therapy (ADT) is a standard treatment as…
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Population Pharmacokinetics Modeling of Monalizumab in Cancer Patients with Longitudinal Patient/Disease Characteristics
Thursday 16 October, 2025
Objectives: Monalizumab is a potentially first-in-class humanized immunoglobulin 4 monoclonal antibody that targets Natural Killer Group 2A (NKG2A), resulting in suppression…
Read morePopulation pharmacokinetic analysis of nonlinear behavior of adefovir
Thursday 16 October, 2025
Objectives: Adefovir dipivoxil, an anti-hepatitis B virus drug[1], is recommended as a phenotyping agent to estimate the activity of the…
Read moreA PKPD model of favipiravir and ribavirin in Lassa virus infected mice
Thursday 16 October, 2025
Objectives: Favipiravir and ribavirin are broad-spectrum antivirals, which showed inhibitory effects against the replication of the Lassa virus in vitro. While…
Read moreLithium pharmacometrics: review of population pharmacokinetics models, external evaluation using non compartmental literature data and model’s updating based on straightforward integration of glomerular filtration rate.
Thursday 16 October, 2025
Introduction: Lithium is recommended in the treatment of bipolar disorder and displays a narrow therapeutic range. Thus, treatment optimization through…
Read moreA Population Pharmacokinetic Model to Assess Variability in Pharmacokinetics of 177Lu-PSMA-617 in Low Volume Metastatic Prostate Cancer Patients
Thursday 16 October, 2025
Objectives: Lutetium-177 Prostate Specific Membrane Antigen (177Lu-PSMA) is a radiopharmaceutical, currently under investigation in phase 3 trials, that shows promising results…
Read moreOptimizing radionuclide therapy with 177Lu-HA-DOTATATE in patients with neuroendocrine tumors using semi-physiological population PK models
Thursday 16 October, 2025
Objectives Somatostatin receptor (SSTR) expression on neuroendocrine tumor (NET) cells enables targeting of NETs with radiopharmaceuticals for both diagnosis (with…
Read moreA Population Pharmacokinetic Model Using Imaging Data to Assess Variability in Pharmacokinetics of 177Lu-PSMA-617 in Low Volume Metastatic Prostate Cancer Patients
Thursday 16 October, 2025
Objectives: Radioligand therapy with Lutetium-177 Prostate Specific Membrane Antigen (177Lu-PSMA) has showed its favorable therapeutic effect in metastatic prostate cancer…
Read moreDeepPumas for automatic discovery of individualizable functions governing longitudinal patient outcomes
Thursday 16 October, 2025
Objectives: The recent advent of Scientific Machine Learning (SciML) that enables us to combine the wealth of knowledge that modelers,…
Read moreLatexify.jl – An ecosystem for automatically transcribing Pumas and Julia objects into renderable equations.
Thursday 16 October, 2025
Objectives: The Julia programming language can represent, modify and execute its own code. This ability is powerful when defining domain-specific…
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