Thursday 16 October, 2025
Objectives: Neutralizing monoclonal antibodies (mAb) to provide novel therapeutics for COVID-19 treatment, were urgently researched from the start of the…
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Population Pharmacokinetics of Unbound Phenytoin after Administration of IV Fosphenytoin And Oral Phenytoin in Pediatric Patients.
Thursday 16 October, 2025
Introduction: Phenytoin is a widely used narrow therapeutic window anti-epileptic drug (1). Total and unbound plasma concentrations of phenytoin have to…
Read moreModel-Based Approach for assessing the Effect of Anti-Drug Antibodies on the PK of Therapeutic Proteins
Thursday 16 October, 2025
Assessments of the impact of antidrug antibodies (ADA) on PK, safety, and efficacy are essential to the clinical development of…
Read moreModelling rate and extent of resistance development against colistin in Klebsiella pneumoniae
Thursday 16 October, 2025
Objectives: Klebsiella pneumonia is a gram-negative pathogen of concern due to widespread multidrug resistance [1]. Colistin is one of the last…
Read moreThe impact of weekend dosing holidays on the evaluation of the sterilizing efficacy of different 4-drug combinations in a relapsing mouse model of Mycobacterium tuberculosis infection using a logistic Emax model
Thursday 16 October, 2025
Introduction/Objectives: Tuberculosis (TB) remains a leading infectious disease-related cause of death worldwide. Current treatment options are extremely long and complex,…
Read moreInvestigating the identifiability of one-stage IVIVC population models for extended-release dosage forms
Thursday 16 October, 2025
Objectives: In-vitro/in-vivo correlation (IVIVC) models can aid in the development of modified-release dosage forms such as extended-release (ER) products [1]….
Read moreEstimators and Confidence Intervals of f2 Using Bootstrap Methodology for the Comparison of Dissolution Profiles
Thursday 16 October, 2025
Introduction/Objectives: Dissolution tests are essential in the development of medicinal products. Among the multiple methods available to compare dissolution profiles,…
Read moreAntiviral Treatment on SARS-Cov-2 Infected Epithelial Tissue Patch
Thursday 16 October, 2025
Objective: Developing antiviral drugs and neutralizing antibodies to treat SARS-CoV-2 infection are currently emerging, and several clinical trials are ongoing…
Read moreEquivalent dose prediction of donepezil patch using population pharmacokinetic oral and patch combination model
Thursday 16 October, 2025
Objectives: Donepezil, a reversible inhibitor of the acetylcholinesterase enzyme, is used to treat mild-to-moderate and severe Alzheimer’s disease (AD). Despite…
Read morerhIL-7-hyFc dose optimization for chemotherapy-induced lymphopenia using FcRn mediated IgG disposition model
Thursday 16 October, 2025
Objectives: The rhIL-7-hyFc (hybrid Fc-fused recombinant human interleukin-7; efineptakin alfa) is a homodimeric interleukin-7 (IL-7) fused to the hybrid Fc…
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