Thursday 16 October, 2025
Objectives: Pharmacological modeling is evolving towards large-scale dynamical models [1]. A typical QSP project may include thousands of molecular components…
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Parameters Estimation, Identifiability and Predictability Analysis in Systems Biology with HetaSimulator and LikelihoodProfiler
Thursday 16 October, 2025
Introduction: Systems Biology and QSP Modeling workflow consists of time consuming and computationally demanding procedures, which include developing a model…
Read moreAn Algorithm to Generate Virtual Patients Cohort for a Model of Solid Tumor Treatment
Thursday 16 October, 2025
Introduction: Conventional QSP modelling approach implies fitting a model to series of mean data values, thus obtaining parameters’ values, which…
Read moreSecure and Scalable Computational Environment for Virtual Patients Simulations
Thursday 16 October, 2025
Introduction: One of the main computational challenges of QSP modeling is the possibility to perform thousands of simulations with large-scale…
Read moreModelling rate and extent of resistance development against colistin in Klebsiella pneumoniae and Pseudomonas aeruginosa
Thursday 16 October, 2025
Objectives: Klebsiella pneumonia (KP) and Pseudomonas aeruginosa (PA) are commonly associated with serious life-threatening infections and antibiotic resistance1. Colistin is…
Read morePopulation plasma and tissue pharmacokinetics of linezolid in healthy volunteers and septic patients
Thursday 16 October, 2025
Background: Linezolid, an antimicrobial drug, is commonly used to treat bacterial pneumonia and skin and soft tissue structure infections (SSTIs)…
Read moreParameter estimation in nonlinear fixed-effects QSP models: benchmark of optimization methods
Thursday 16 October, 2025
Objectives: Robust and efficient parameter estimation is one of the key steps in quantitative systems pharmacology (QSP) model development. The problem…
Read morePharmacokinetic, receptor occupancy and pharmacodynamic (PK/RO/PD) modeling of ALX148, a CD47 blocker
Thursday 16 October, 2025
Introduction: ALX148 is a promising anti-CD47 blocker currently undergoing clinical trials, which is designed to enhance the activity of anti-cancer…
Read moreDevelopment and validation of a population pharmacokinetic model for donepezil
Thursday 16 October, 2025
Objectives: Donepezil is a widely used drug for symptomatic relief of Alzheimer’s disease. Clinical trial data indicate high variability among…
Read morePopulation Pharmacokinetics of Valproic Acid, Lamotrigine, and Levetiracetam in the Pediatric Population
Thursday 16 October, 2025
Introduction: Managing epilepsy in pediatric patients through combined pharmacotherapy is a challenging task for clinicians. This is due to the…
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